A rare case of plasmablastic lymphoma with MDM2 overexpression and amplification

Abstract

We describe a challenging differential diagnosis of a poorly differentiated tumor arising in the abdominal cavity of a 76-year-old woman. After histological and immunohistochemical analysis the differential diagnosis between a plasmablastic lymphoma (PBL) and a dedifferentiated liposarcoma remained. Molecular testing was necessary to make a definite diagnosis of PBL. To the best of our knowledge, this is the first report in literature of PBL with MDM2 overexpression and amplification. Awareness of this finding could prove useful for appropriate patient management.