Clinicopathological study on local recurrence of primary oral squamous cell carcinoma

Abstract

A clinicopathological study, focusing on local recurrence, was performed on 107 patients who were histologically diagnosed with oral squamous cell carcinoma and who underwent radical surgery at the Department of Oral and Maxillofacial Surgery of Nagoya Ekisaikai Hospital between January 2007 and March 2020. Among these 107 patients, 14 developed local recurrence with a recurrence rate of 13.1％. The median interval between surgery and local recurrence was 293.5 days （range: 21-1,408 days）. An analysis of the risk factors for local recurrence was performed, and depth of invasion was identified as an independent risk factor. Salvage treatments included surgery in 7 patients, radiation and chemoradiotherapy in 4 patients, and palliative care in 3 patients. Seven of the 11 patients （63.6％） were successfully salvaged. Analysis of the patients with local recurrence showed that the surgery resulted in a better outcome. However, further studies are needed to analyze the risk factors for the recurrence and efficacy of the salvage treatments from multiple perspectives.