Correlation of CO-RADS Score with Inflammatory Markers in COVID-19 Patients: A Retrospective Analysis at a Designated COVID Centre of Kolhapur, India

Sapna S Deshpande, Namrata B Mestri, C. Patil
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Abstract

Introduction: Coronavirus Disease-2019 (COVID-19) Reporting and Data System (CO-RADS) score in Computed Tomography (CT) scan of the chest is a priority investigation in early identification of the disease. Although, a CT scan gives a clear parenchymal picture of the condition, it has its disadvantages of the cost and specificity in the prognosis of COVID-19. In addition, clinical studies have revealed its decreased utility in assessing the severity of the disease. Aim: To understand the correlation of the CO-RADS score with various inflammatory markers and explore the changes in CO- RADS score with the severity of COVID-19 infection. Materials and Methods: The present study is a retrospective observational study in a designated COVID-19 centre in Kolhapur, India. The radiological and pathological records of 64 cases for two months (September to October 2020) were reviewed and charted. The present study included all the cases over 18 years. The authors excluded pregnant women, patients with tuberculosis, interstitial lung disease, and pulmonary malignancy with a view of interference with the radiological presentation of COVID- 19. Along with demographics, biomarkers like Total Leucocyte Count (TLC), C-Reactive Protein (CRP), Lactate Dehydrogenase (LDH), D-Dimer, Interleukin-6 (IL-6), Procalcitonin (PCT), and serum ferritin were retrospectively reviewed and documented. The CO-RADS score, as reported by an expert radiologist, was noted down. Pearson’s correlation coefficient was used to correlate the CO-RADS score with various inflammatory markers. Results: The authors found significant high positive correlation of CT score with LDH (r=0.754; p-value <0.001), moderate positive correlation with IL-6 (r=0.503; p-value <0.001), low positive correlation with CRP (r=0.477; p-value <0.001) and PCT (r=0.461; p-value <0.001). The correlation between the CT score with serum ferritin (r=0.284; p-value=0.023), total leukocyte count (r=0.260; p-value=0.038) and D-dimer (r=0.242; p-value 0.050) was negligible. Conclusion: The CO-RADS CT score is associated with the severity of COVID-19 disease and with mortality. The CO-RADS score showed a high positive correlation with LDH values of the present study. The LDH seems to be a promising marker and has to be further evaluated in assessing early COVID-19 infection with a multi-centric and more extensive sample size approach.
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COVID-19患者CO-RADS评分与炎症标志物的相关性:印度科尔哈布尔指定COVID中心的回顾性分析
简介:冠状病毒病-2019 (COVID-19)报告和数据系统(CO-RADS)在胸部计算机断层扫描(CT)扫描中的评分是早期识别该疾病的优先调查。尽管CT扫描可以清晰地显示病情的实质图像,但它在COVID-19预后方面存在成本和特异性的缺点。此外,临床研究显示其在评估疾病严重程度方面的效用有所下降。目的:了解CO-RADS评分与各种炎症标志物的相关性,探讨CO-RADS评分随COVID-19感染严重程度的变化。材料和方法:本研究是在印度科尔哈布尔指定的COVID-19中心进行的回顾性观察性研究。对64例患者2个月(2020年9月至10月)的影像学和病理记录进行回顾并作图。本研究纳入了18年以上的所有病例。作者排除了孕妇、结核病患者、间质性肺疾病患者和肺部恶性肿瘤患者,因为它们干扰了COVID- 19的影像学表现。随着人口统计学,生物标志物如总白细胞计数(TLC), c反应蛋白(CRP),乳酸脱氢酶(LDH), d -二聚体,白细胞介素-6 (IL-6),降钙素原(PCT),血清铁蛋白被回顾性回顾和记录。由放射科专家报告的CO-RADS评分被记录下来。使用Pearson相关系数将CO-RADS评分与各种炎症标志物进行关联。结果:CT评分与LDH呈正相关(r=0.754;p值<0.001),与IL-6中度正相关(r=0.503;p值<0.001),与CRP呈低正相关(r=0.477;p值<0.001)和PCT (r=0.461;假定值< 0.001)。CT评分与血清铁蛋白的相关性(r=0.284;p值=0.023),白细胞总数(r=0.260;p值=0.038)和d -二聚体(r=0.242;p值为0.050)可以忽略不计。结论:CO-RADS CT评分与COVID-19疾病严重程度及死亡率相关。本研究CO-RADS评分与LDH值呈高度正相关。LDH似乎是一个很有前景的标志物,需要通过多中心和更广泛的样本量方法来进一步评估早期COVID-19感染。
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审稿时长
12 weeks
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