Bioactive lipids and herbal therapeutic regimens in the management of emerging SARS-CoV-2 variants: Further insights

Balkrishna Acharya, Ashwani Kumar, V. Arya
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Abstract

Despite the development and implementation of vaccinations, the SARS-CoV-2 pandemic has persisted for more than two years due to emerging novel variants. The new Omicron lineages are being intensively monitored by WHO. Scientists from all over the world have reported the recombinant variants, but their existence remains a point of contention. Currently, XE and BA.2 are the most common variants. Deltracron (a recombinant of Delta and Omicron) has been discovered in several investigations, although some experts believe the sequences that confirm its emergence are the product of contamination. This study looked at emerging variants including XD, XE, and XF, as well as various omicron lineages (BA.1, BA.2, BA.3, BA.4, and BA.5). Bioactive lipids including arachidonic acid, docosahexaenoic acid, and eicosapentaenoic acid have been highlighted as possible COVID-19 therapeutics. On the other hand, herbal remedies are supposed to be the key player in minimizing the fatality rates in India. Coronil, a herbal formulation was found to be the evidence-based medicine against SARS-CoV-2. The activity of the Coronil is attributed to its diverse bioactive composition which includes cordifolioside A, rosmarinic acid, magnoflorine, withaferin A, ursolic acid, withanone, palmatine, betulinic acid, withanoside IV, and withanoside V. The interaction of bioactive lipids, Coronil and SARS-CoV-2 emerging variants might be beneficial in the management of pandemic until the herd immunity is achieved.
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生物活性脂质和草药治疗方案在新出现的SARS-CoV-2变体管理中的应用:进一步的见解
尽管开发和实施了疫苗接种,但由于新变体的出现,SARS-CoV-2大流行持续了两年多。世卫组织正在密切监测新的欧米克隆谱系。世界各地的科学家都报道了重组变种,但它们的存在仍然是争论的焦点。目前,XE和BA.2是最常见的变体。在几项调查中发现了deltrron (Delta和Omicron的重组产物),尽管一些专家认为证实其出现的序列是污染的产物。这项研究研究了包括XD、XE和XF在内的新兴变异,以及各种组粒谱系(BA.1、BA.2、BA.3、BA.4和BA.5)。生物活性脂质包括花生四烯酸、二十二碳六烯酸和二十碳五烯酸已被强调为可能的COVID-19治疗药物。另一方面,草药被认为是降低印度死亡率的关键因素。草药制剂“Coronil”被发现是针对新冠病毒的循证药物。冠状叶的活性归因于其多种生物活性成分,包括堇叶苷A、迷迭香酸、木兰花碱、withaferin A、熊果酸、withanone、棕榈碱、白桦酸、withano苷IV和withano苷v。生物活性脂质、冠状叶和SARS-CoV-2新变体的相互作用可能对大流行的管理有益,直到实现群体免疫。
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CiteScore
0.80
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0.00%
发文量
38
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