A study on the therapeutic potential of graphene titanate nanocomposite for treating chemically induced arthritis in rats.

IF 4.5 3区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2023-12-01 Epub Date: 2023-10-30 DOI:10.1080/21691401.2023.2268653

Amany Belal, Mohamed Y Zaky, Doaa S Mohamed, Eman E Mohamed, Rehab Mahmoud, Doaa Essam, R R Atta, Fatma I Abo El-Ela, Fatma Mohamed Halfaya, Kyung-Tae Lee, Ahmed H E Hassan, Mohammed M Ghoneim, Ahmed Farghali

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Abstract

Nanotechnology holds substantial promise in the innovative therapies for rheumatoid arthritis (RA). The current study was designed to synthesize and characterize a new graphene titanate nanocomposite (GTNc) and explore its anti-arthritic, anti-inflammatory, and antioxidant potencies against Complete Freund's adjuvant (CFA)-induced arthritis in rats, as well as investigate the underlying molecular mechanisms. Our characterization methods included XRD, FT-IR, SEM, EDX, zeta potential, practical size, and XRF to characterize the novel GTNc. Our findings revealed that arthritic rats treated with GTNc exhibited lower levels of RF, CRP, IL-1β, TNF-α, IL-17, and ADAMTS-5, and higher levels of IL-4 and TIMP-3. In arthritic rats, GTNc reduced LPO levels while increasing GSH content and GST antioxidant activity. Additionally, GTNc decreased the expression of the TGF-β mRNA gene in arthritic rats. Histopathological investigation showed that GTNc reduced inflammatory cell infiltration, cartilage degradation, and bone destruction in joint injuries caused by CFA in the arthritic rats. Collectively, the anti-arthritic, anti-inflammatory, and antioxidant properties of GTNc appear promising for future arthritis treatments and bone disability research.

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钛酸石墨烯纳米复合材料治疗化学诱导的大鼠关节炎的潜力研究。

纳米技术在类风湿性关节炎（RA）的创新疗法中有着巨大的前景。本研究旨在合成和表征一种新型钛酸石墨烯纳米复合材料（GTNc），探索其对完全弗氏佐剂（CFA）诱导的大鼠关节炎的抗关节炎、抗炎和抗氧化能力，并研究其潜在的分子机制。我们的表征方法包括XRD、FT-IR、SEM、EDX、ζ电位、实际尺寸和XRF来表征新型GTNc。我们的研究结果显示，GTNc治疗的关节炎大鼠表现出较低水平的RF、CRP、IL-1β、TNF-α、IL-17和ADAMTS-5，以及较高水平的IL-4和TIMP-3。在关节炎大鼠中，GTNc降低LPO水平，同时增加GSH含量和GST抗氧化活性。此外，GTNc降低了关节炎大鼠TGF-βmRNA基因的表达。组织病理学研究表明，GTNc减少了关节炎大鼠CFA引起的关节损伤中的炎症细胞浸润、软骨降解和骨破坏。总的来说，GTNc的抗关节炎、抗炎和抗氧化特性似乎有望用于未来的关节炎治疗和骨残疾研究。

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来源期刊

Artificial Cells, Nanomedicine, and Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ENGINEERING, BIOMEDICAL

CiteScore

10.90

自引率

0.00%

发文量

审稿时长

20 weeks

期刊介绍： Artificial Cells, Nanomedicine and Biotechnology covers the frontiers of interdisciplinary research and application, combining artificial cells, nanotechnology, nanobiotechnology, biotechnology, molecular biology, bioencapsulation, novel carriers, stem cells and tissue engineering. Emphasis is on basic research, applied research, and clinical and industrial applications of the following topics:artificial cellsblood substitutes and oxygen therapeuticsnanotechnology, nanobiotecnology, nanomedicinetissue engineeringstem cellsbioencapsulationmicroencapsulation and nanoencapsulationmicroparticles and nanoparticlesliposomescell therapy and gene therapyenzyme therapydrug delivery systemsbiodegradable and biocompatible polymers for scaffolds and carriersbiosensorsimmobilized enzymes and their usesother biotechnological and nanobiotechnological approachesRapid progress in modern research cannot be carried out in isolation and is based on the combined use of the different novel approaches. The interdisciplinary research involving novel approaches, as discussed above, has revolutionized this field resulting in rapid developments. This journal serves to bring these different, modern and futuristic approaches together for the academic, clinical and industrial communities to allow for even greater developments of this highly interdisciplinary area.