Retrieval and savings of contextual fear memories across an extended retention interval in juvenile and adult male and female rats.

IF 1.6 4区 医学 Q3 BEHAVIORAL SCIENCES Behavioral neuroscience Pub Date : 2023-12-01 Epub Date: 2023-10-30 DOI:10.1037/bne0000569
Natalie Odynocki, Zerah Isaacs, Andrew M Poulos
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Abstract

Adult rodents exhibit an exceptional ability to retrieve context fear memories across lengthy retention intervals. In contrast, these memories established in younger rodents are susceptible to significant forgetting. The present study aimed to examine the persistence of contextual fear memories established in juvenile and adult Long-Evans male and female rats. Testing 1-day after conditioning, adult males exhibited evidence for greater conditioning than juvenile males, while in females, conditioning did not differ between juvenile and adult rats. In adults, males displayed greater conditioning than females, while in juveniles, males and females reached similar conditioning levels. At the 60-day retention interval, adult sex differences were maintained; however, juvenile rats failed to retrieve this remote contextual fear memory. Next, we examined whether a savings test procedure could recover these remotely established juvenile memories. Following a 60-day retention test, the now adult rats were presented with an additional context-shock pairing to assess the level of savings. While this procedure produced greater conditioning in males than females, the relative savings of this early life memory were similar in males and females. The results of these experiments indicate that adult sex differences in contextual fear memory are maintained across an extended retention interval, while in juveniles, there were no significant sex differences. A novel finding in the present study was that both male and female rats failed to retrieve an initial juvenile memory following an extended retention interval. However, these memories were recovered with a single reminder of the original juvenile experience. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

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在幼年和成年雄性和雌性大鼠中,在延长的保留期内检索和保存上下文恐惧记忆。
成年啮齿动物表现出在长时间的保留期内检索上下文恐惧记忆的非凡能力。相比之下,这些在年轻啮齿动物身上建立的记忆容易被严重遗忘。本研究旨在检验在幼年和成年Long-Evans雄性和雌性大鼠中建立的情境恐惧记忆的持久性。在条件作用后1天的测试中,成年雄性大鼠表现出比幼年雄性大鼠更强的条件作用,而在雌性大鼠中,幼年大鼠和成年大鼠的条件作用没有差异。在成年人中,雄性表现出比雌性更强的条件反射,而在青少年中,雄性和雌性达到了相似的条件反射水平。在60天的保留期,保持了成人性别差异;然而,幼鼠未能恢复这种遥远的情境恐惧记忆。接下来,我们研究了储蓄测试程序是否可以恢复这些远程建立的青少年记忆。经过60天的滞留测试,现在成年的大鼠接受了额外的情境冲击配对,以评估节省的水平。虽然这种程序在男性中比女性产生了更大的条件反射,但在男性和女性中,这种早期生活记忆的相对节省是相似的。这些实验的结果表明,成年人在情境恐惧记忆中的性别差异在延长的保留期内保持不变,而在青少年中,没有显著的性别差异。本研究中的一项新发现是,雄性和雌性大鼠在延长保留期后都未能恢复最初的幼年记忆。然而,这些记忆是通过一个单一的提醒来恢复的,那就是最初的青少年经历。(PsycInfo数据库记录(c)2023 APA,保留所有权利)。
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来源期刊
Behavioral neuroscience
Behavioral neuroscience 医学-行为科学
CiteScore
3.40
自引率
0.00%
发文量
51
审稿时长
6-12 weeks
期刊介绍: Behavioral Neuroscience publishes original research articles as well as reviews in the broad field of the neural bases of behavior.
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