Physical Activity, Sedentary Behavior, and Osteoarthritis: A Two-Sample Mendelian Randomization Analysis.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-10-01 DOI:10.18502/ijph.v52i10.13848

Yanpeng Wang, Yinzhen Zhang, Changwei Zhao, Wenjun Cai, Zhengyan Wang, Wenhai Zhao

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Abstract

Background: Sedentary behavior and physical activity are still ambiguous in their effects on osteoarthritis. We aimed to evaluate the effects of physical activity and sedentary behavior on osteoarthritis to provide a reference for the prevention of osteoarthritis.

Methods: This study was conducted in Changchun, China in 2022. We used two-sample Mendelian randomization with the SNP as an instrumental variable to investigate the effect of physical activity and sedentary behavior on osteoarthritis. In addition, a two-step Mendelian randomization method was used to test whether mediating factors (BMI, smoking, Apolipoprotein B) were involved in mediating the effects of exposure factors on osteoarthritis.

Results: TV watching was causally related to knee osteoarthritis and spine osteoarthritis, and they were positively correlated (knee osteoarthritis: OR=1.162,95 %CI: 1.027-1.315, P=0.017; spine osteoarthritis: OR=1.208,95 %CI: 1.033-1.413, P=0.018). BMI played a mediating role in the process of TV watching with knee osteoarthritis and spine osteoarthritis. ((The proportion of BMI mediating effect: knee osteoarthritis: 47.1% (95% CI: 36.7%~63.2%); spine osteoarthritis: 29.5% (95% CI: 19.3%~40.8%)). The proportion of Smoking mediating effect in the process of TV watching with spine osteoarthritis was 16.1% (95% CI: 3.7% ~ 31.6%).

Conclusion: TV watching is a potential risk factor for osteoarthritis and plays a role through modifiable factors such as BMI and smoking, therefore, interventions on these factors have the potential to reduce the burden of osteoarthritis caused by longer TV watching times.

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体力活动、久坐行为和骨关节炎：两个样本的孟德尔随机化分析。

背景：久坐行为和体育活动对骨关节炎的影响尚不明确。我们旨在评估体育活动和久坐行为对骨关节炎的影响，为预防骨关节炎提供参考。方法：本研究于2022年在中国长春进行。我们使用两个样本的孟德尔随机化，以SNP为工具变量来研究体育活动和久坐行为对骨关节炎的影响。此外，使用两步孟德尔随机化方法来测试介导因素（BMI、吸烟、载脂蛋白B）是否参与介导暴露因素对骨关节炎的影响。结果：看电视与膝关节骨性关节炎和脊柱骨关节炎有因果关系，且呈正相关（膝关节骨关节炎：OR=1.122，95%CI:1.027-1.315，P=0.017；脊柱骨关节病：OR=1.208，95%CI:1.033-1.413，P=0.018）。（BMI介导作用的比例：膝骨关节炎：47.1%（95%CI:36.7%~63.2%）；脊柱骨关节炎：29.5%（95%CI:19.3%~40.8%）。吸烟在脊柱骨关节病看电视过程中的中介作用比例为16.1%（95%CI:3.7%~31.6%）。结论：看电视是骨关节炎的潜在危险因素，通过BMI和吸烟等可改变因素发挥作用，对这些因素的干预有可能减轻因看电视时间过长而引起的骨关节炎的负担。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.