Association between preoperative modifiable lifestyle factors and mortality after cancer surgery: a population-based cohort study in South Korea.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2023-10-01 Epub Date: 2023-09-27 DOI:10.4174/astr.2023.105.4.179

Tak Kyu Oh, In-Ae Song

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Abstract

Purpose: We aimed to examine whether preoperative lifestyle factors are associated with mortality after cancer surgery.

Methods: This study used data from the National Health Insurance Service database in South Korea. We included all adult patients who underwent major cancer surgery between January 1, 2016, and December 31, 2018. Three lifestyle factors were evaluated preoperatively: smoking status, alcohol consumption, and physical activity.

Results: A total of 48,557 patients who underwent major cancer surgery were included in the final analysis. In the multivariable logistic regression modeling, current smokers showed 1.40-fold higher odds of 90-day mortality after cancer surgery (odds ratio, 1.40; 95% confidence interval, 1.14-1.71; P = 0.001) than never smokers. However, alcohol consumption and physical activity were not associated with 90-day mortality after cancer surgery. In the multivariable Cox regression modeling, current smokers showed 1.25-fold higher odds of 1-year mortality after cancer surgery (hazard ratio, 1.25; 95% confidence interval, 1.13-1.38; P < 0.001) than never smokers. However, alcohol consumption and physical activity were not associated with 1-year mortality after cancer surgery.

Conclusion: In conclusion, current smoking was associated with worse short- and long-term survival outcomes in South Korea, though preoperative alcohol consumption and physical activity levels were not associated with mortality after cancer surgery.

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术前可改变的生活方式因素与癌症手术后死亡率的相关性：韩国一项基于人群的队列研究。

目的：我们旨在检查术前生活方式因素是否与癌症手术后死亡率相关。方法：本研究使用了韩国国家健康保险服务数据库的数据。我们纳入了2016年1月1日至2018年12月31日期间接受癌症大手术的所有成年患者。术前评估了三个生活方式因素：吸烟状况、饮酒量和体育活动。结果：共有48557名接受癌症大手术的患者被纳入最终分析。在多变量逻辑回归模型中，目前吸烟者在癌症手术后90天的死亡率是从不吸烟者的1.40倍（比值比，1.40；95%置信区间，1.14-1.71；P=0.001）。然而，饮酒和体育活动与癌症手术后90天的死亡率无关。在多变量Cox回归模型中，目前吸烟者在癌症手术后1年死亡率（危险比为1.25；95%置信区间为1.13-1.38；P<0.001）比从不吸烟者高1.25倍。然而，饮酒和体育活动与癌症手术后1年死亡率无关。结论：总之，尽管术前饮酒量和体力活动水平与癌症手术后的死亡率无关，但在韩国，目前的吸烟与较差的短期和长期生存结果有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.