Distribution patterns of human papillomavirus genotypes among women in Guangzhou, China.

IF 3.1 2区医学 Q3 IMMUNOLOGY Infectious Agents and Cancer Pub Date : 2023-10-31 DOI:10.1186/s13027-023-00541-8

Shu Li, Kelan Zhang, Liu Yang, Jia Wu, Neha Bhargava, Yinghua Li, Fei Gao

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Abstract

Background: Cervical cancer is associated with high-risk human papillomavirus (HR-HPV) infection in the world. We aimed to evaluate the status of HPV infection among women in Guangzhou, China.

Methods: The study recruited 28,643 female patients from the Guangzhou Women and Children's Medical Center for HPV genotype testing between 2019 and 2021.

Results: 5668 patients were infected with HPV, resulting in an overall infection prevalence of 19.78%. The prevalence of HR-HPV was recorded at 13.94% (both single-infections and multi-infections), probably high-risk HPV/possibly carcinogenic (pHR-HPV) as 3.51%; and low-risk HPV (LR-HPV) as 3.56%. The most common HR-HPV genotype detected was HPV-52 with an infection rate of 4.99%, followed by HPV 58 (2.18%), 16 (2.12%), 51 (1.61%), 39 (1.19%), 56 (1.09%), 59 (0.85%), 18 (0.72%), 33 (0.61%), 31 (0.53%), 35 (0.20%), 45 (0.17%). Among LR-HPV genotypes, HPV-42 was the most common (1.08%), followed by 44 (0.77%), 81 (0.68%), 6 (0.48%), 43 (0.40%), 11 (0.23%) and 83 (0.07%). The prevalence of infection among different genotypes in pHR-HPV was: 68 (1.29%), 53 (1.21%), 66 (0.77%), 82 (0.25%), 73 (0.16%). Additionally, the prevalence of single genotype HPV infection exceeded that of multiple HPV infections except HPV-59.

Conclusion: Our findings imply that HPV genotype infections in Guangzhou demonstrate a regional and age-related distribution. Therefore, these data can provide a substantial foundation for further epidemiologic analysis to control and prevent HPV infections in Guangzhou.

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中国广州女性中人乳头瘤病毒基因型的分布模式。

背景：在世界范围内，癌症与高危型人乳头瘤病毒（HR-HPV）感染相关。我们旨在评估中国广州女性HPV感染状况。方法：本研究招募了广州市妇幼保健中心28643名女性患者，在2019年至2021年间进行HPV基因型检测。结果：5668名患者感染了HPV，导致总感染率为19.78%。HR-HPV的患病率记录为13.94%（单次感染和多次感染），可能是高危HPV/可能致癌（pHR-HPV）为3.51%；最常见的HR-HPV基因型是HPV-52，感染率为4.99%，其次是HPV 58（2.18%）、16（2.12%）、51（1.61%）、39（1.19%）、56（1.09%）、59（0.85%）、18（0.72%）、33（0.61%）、31（0.53%）、35（0.20%）、45（0.17%）。0.48%）、43（0.40%），11（0.23%）和83（0.07%）。不同基因型的pHR HPV感染率分别为：68（1.29%）、53（1.21%）、66（0.77%）、82（0.25%）、73（0.16%），单基因型HPV感染的患病率高于除HPV-59以外的多种HPV感染。结论：我们的研究结果表明，广州地区的HPV基因型感染呈区域性和年龄相关性分布。因此，这些数据可以为进一步的流行病学分析提供实质性的基础，以控制和预防广州市的HPV感染。

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来源期刊

Infectious Agents and Cancer ONCOLOGY-IMMUNOLOGY

CiteScore

5.80

自引率

2.70%

发文量

期刊介绍： Infectious Agents and Cancer is an open access, peer-reviewed online journal that encompasses all aspects of basic, clinical, epidemiological and translational research providing an insight into the association between chronic infections and cancer. The journal welcomes submissions in the pathogen-related cancer areas and other related topics, in particular: • HPV and anogenital cancers, as well as head and neck cancers; • EBV and Burkitt lymphoma; • HCV/HBV and hepatocellular carcinoma as well as lymphoproliferative diseases; • HHV8 and Kaposi sarcoma; • HTLV and leukemia; • Cancers in Low- and Middle-income countries. The link between infection and cancer has become well established over the past 50 years, and infection-associated cancer contribute up to 16% of cancers in developed countries and 33% in less developed countries. Preventive vaccines have been developed for only two cancer-causing viruses, highlighting both the opportunity to prevent infection-associated cancers by vaccination and the gaps that remain before vaccines can be developed for other cancer-causing agents. These gaps are due to incomplete understanding of the basic biology, natural history, epidemiology of many of the pathogens that cause cancer, the mechanisms they exploit to cause cancer, and how to interrupt progression to cancer in human populations. Early diagnosis or identification of lesions at high risk of progression represent the current most critical research area of the field supported by recent advances in genomics and proteomics technologies.