Diet-induced changes in functional disability are mediated by fatigue in relapsing-remitting multiple sclerosis: A secondary analysis of the WAVES randomized parallel-arm trial.

IF 2.5 Q2 CLINICAL NEUROLOGY Multiple Sclerosis Journal - Experimental, Translational and Clinical Pub Date : 2023-10-30 eCollection Date: 2023-10-01 DOI:10.1177/20552173231209147
Landon J Crippes, Solange M Saxby, Farnoosh Shemirani, Babita Bisht, Christine Gill, Linda M Rubenstein, Patrick Ten Eyck, Lucas J Carr, Warren G Darling, Karin F Hoth, John Kamholz, Linda G Snetselaar, Tyler J Titcomb, Terry L Wahls
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Abstract

Background: People with multiple sclerosis (MS) often report dietary modifications; however, evidence on functional outcomes remains sparse.

Objective: Evaluate the impact of the low-saturated fat (Swank) and modified Paleolithic elimination (Wahls) diets on functional disability among people with relapsing-remitting MS.

Methods: Baseline-referenced MS functional composite (MSFC) scores were calculated from nine-hole peg-test (NHPT), timed 25-foot walk, and oral symbol digit modalities test (SDMT-O) collected at four study visits: (a) run-in, (b) baseline, (c) 12 weeks, and (d) 24 weeks. Participants were observed at run-in and then randomized at baseline to either the Swank (n = 44) or Wahls (n = 43) diets.

Results: Among the Swank group, MSFC scores significantly increased from -0.13 ± 0.14 at baseline to 0.10 ± 0.11 at 12 weeks (p = 0.04) and 0.14 ± 0.11 at 24 weeks (p = 0.02). Among the Wahls group, no change in MSFC scores was observed at 12 weeks from 0.10 ± 0.11 at baseline but increased to 0.28 ± 0.13 at 24 weeks (p = 0.002). In both groups, NHPT and SDMT-O z-scores increased at 24 weeks. Changes in MSFC and NHPT were mediated by fatigue.

Discussion: Both diets reduced functional disability as mediated by fatigue.

Trial registration: Clinicaltrials.gov Identifier: NCT02914964.

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复发缓解型多发性硬化症的疲劳介导了饮食诱导的功能性残疾变化:WAVES随机平行臂试验的二次分析。
背景:多发性硬化症患者经常报告饮食改变;然而,关于功能结果的证据仍然很少。目的:评估低饱和脂肪(Swank)和改良旧石器时代消除(Wahls)饮食对复发-缓解型MS患者功能残疾的影响,以及在四次研究访视中收集的口腔符号数字模式测试(SDMT-O):(a)磨合期,(b)基线,(c)12周和(d)24周。参与者在磨合时被观察,然后在基线时被随机分配到Swank(n = 44)或Wahls(n = 43)饮食。结果:在Swank组中,MSFC评分从-0.13显著增加 ± 基线时0.14至0.10 ± 12周时0.11(p = 0.04)和0.14 ± 第24周为0.11(p = 0.02)。在Wahls组中,在12周时未观察到MSFC评分从0.10变化 ± 基线时为0.11,但增加到0.28 ± 24周时0.13(p = 0.002)。在两组中,NHPT和SDMT-O z评分在24周时增加。MSFC和NHPT的变化是由疲劳介导的。讨论:这两种饮食都能减少由疲劳引起的功能性残疾。试验注册:Clinicaltrials.gov标识符:NCT02914964。
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来源期刊
CiteScore
4.70
自引率
0.00%
发文量
54
审稿时长
15 weeks
期刊最新文献
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