Effects of Probiotic-Enriched Minas Cheese (Lactobacillus acidophilus La-05) on Cardiovascular Parameters in 5/6 Nephrectomized Rats.

IF 4.4 2区生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Probiotics and Antimicrobial Proteins Pub Date : 2025-04-01 Epub Date: 2023-11-02 DOI:10.1007/s12602-023-10173-4

Nathalia da Silva Costa, Joana Ramos de Araujo, Manuela Fernandes da Silva Melo, Jéssica da Costa Mota, Patricia Pereira Almeida, Karen Salve Coutinho-Wolino, Beatriz Oliveira Da Cruz, Michele Lima Brito, Thaís de Souza Carvalho, Emanuelle Barreto-Reis, Beatriz Gouvêa de Luca, Denise Mafra, D 'Angelo Carlo Magliano, Renato de Souza Abboud, Ramon Silva Rocha, Adriano Gomes da Cruz, Jonas de Toledo Guimarães, Milena Barcza Stockler-Pinto

{"title":"Effects of Probiotic-Enriched Minas Cheese (Lactobacillus acidophilus La-05) on Cardiovascular Parameters in 5/6 Nephrectomized Rats.","authors":"Nathalia da Silva Costa, Joana Ramos de Araujo, Manuela Fernandes da Silva Melo, Jéssica da Costa Mota, Patricia Pereira Almeida, Karen Salve Coutinho-Wolino, Beatriz Oliveira Da Cruz, Michele Lima Brito, Thaís de Souza Carvalho, Emanuelle Barreto-Reis, Beatriz Gouvêa de Luca, Denise Mafra, D 'Angelo Carlo Magliano, Renato de Souza Abboud, Ramon Silva Rocha, Adriano Gomes da Cruz, Jonas de Toledo Guimarães, Milena Barcza Stockler-Pinto","doi":"10.1007/s12602-023-10173-4","DOIUrl":null,"url":null,"abstract":"Dairy foods have become an interest in chronic kidney disease (CKD) due to their nutritional profile, which makes them a good substrate for probiotics incorporation. This study evaluated the effect of probiotic-enriched Minas cheese with Lactobacillus acidophilus La-05 in an experimental rat model for CKD on cardiac, inflammatory, and oxidative stress parameters. Male Wistar rats were divided into 4 groups (n = 7/group): 5/6 nephrectomy + conventional Minas cheese (NxC); 5/6 nephrectomy + probiotic Minas cheese (NxPC); Sham + conventional Minas cheese (ShamC); Sham + probiotic Minas cheese (ShamPC). Offering 20 g/day of Minas cheese with Lact. acidophilus La-05 (108-109 log CFU/g) for 6 weeks. The cardiomyocyte diameter was determined. Superoxide dismutase (SOD) activity in plasma, heart, kidney, and colon tissue was performed. At the end of supplementation, no significant changes in lipid profile and renal parameters were found. The NxPC group showed a decrease in cardiomyocyte diameter compared to the NxC group (16.99 ± 0.85 vs. 19.05 ± 0.56 μm, p = 0.0162); also they showed reduced plasmatic SOD activity (502.8 ± 49.12 vs. 599.4 ± 94.69 U/mL, p < 0.0001). In summary, probiotic-enriched Minas cheese (Lact. acidophilus La-05) consumption suggests a promisor cardioprotective effect and was able to downregulate SOD activity in a rat model of CKD.","PeriodicalId":20506,"journal":{"name":"Probiotics and Antimicrobial Proteins","volume":" ","pages":"873-887"},"PeriodicalIF":4.4000,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Probiotics and Antimicrobial Proteins","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s12602-023-10173-4","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/11/2 0:00:00","PubModel":"Epub","JCR":"Q1","JCRName":"BIOTECHNOLOGY & APPLIED MICROBIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Dairy foods have become an interest in chronic kidney disease (CKD) due to their nutritional profile, which makes them a good substrate for probiotics incorporation. This study evaluated the effect of probiotic-enriched Minas cheese with Lactobacillus acidophilus La-05 in an experimental rat model for CKD on cardiac, inflammatory, and oxidative stress parameters. Male Wistar rats were divided into 4 groups (n = 7/group): 5/6 nephrectomy + conventional Minas cheese (NxC); 5/6 nephrectomy + probiotic Minas cheese (NxPC); Sham + conventional Minas cheese (ShamC); Sham + probiotic Minas cheese (ShamPC). Offering 20 g/day of Minas cheese with Lact. acidophilus La-05 (10⁸-10⁹ log CFU/g) for 6 weeks. The cardiomyocyte diameter was determined. Superoxide dismutase (SOD) activity in plasma, heart, kidney, and colon tissue was performed. At the end of supplementation, no significant changes in lipid profile and renal parameters were found. The NxPC group showed a decrease in cardiomyocyte diameter compared to the NxC group (16.99 ± 0.85 vs. 19.05 ± 0.56 μm, p = 0.0162); also they showed reduced plasmatic SOD activity (502.8 ± 49.12 vs. 599.4 ± 94.69 U/mL, p < 0.0001). In summary, probiotic-enriched Minas cheese (Lact. acidophilus La-05) consumption suggests a promisor cardioprotective effect and was able to downregulate SOD activity in a rat model of CKD.

Abstract Image

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

富含益生菌的米纳斯奶酪（嗜酸乳杆菌La-05）对5/6肾切除大鼠心血管参数的影响。

乳制品由于其营养特性而成为慢性肾脏病（CKD）的研究热点，这使其成为益生菌掺入的良好基质。本研究在CKD实验大鼠模型中评估了富含益生菌的米纳斯奶酪与嗜酸乳杆菌La-05对心脏、炎症和氧化应激参数的影响。雄性Wistar大鼠分为4组（n = 7/组）：5/6肾切除术 + 传统米纳斯奶酪（NxC）；5/6肾切除术 + 益生菌米纳斯奶酪（NxPC）；伪装 + 传统米纳斯奶酪（ShamC）；伪装 + 益生菌米纳斯奶酪（ShamPC）。提供20克/天的米纳斯奶酪和乳酸。嗜酸乳杆菌La-05（108-109 log CFU/g）培养6周。测定心肌细胞直径。检测血浆、心脏、肾脏和结肠组织中的超氧化物歧化酶（SOD）活性。在补充结束时，没有发现脂质状况和肾脏参数的显著变化。与NxC组相比，NxPC组心肌细胞直径减小（16.99 ± 0.85对19.05 ± 0.56μm，p = 0.0162）；他们还显示出血浆SOD活性降低（502.8 ± 49.12对599.4 ± 94.69 U/mL，p

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Probiotics and Antimicrobial Proteins BIOTECHNOLOGY & APPLIED MICROBIOLOGYMICROB-MICROBIOLOGY

CiteScore

11.30

自引率

6.10%

发文量

140

期刊介绍： Probiotics and Antimicrobial Proteins publishes reviews, original articles, letters and short notes and technical/methodological communications aimed at advancing fundamental knowledge and exploration of the applications of probiotics, natural antimicrobial proteins and their derivatives in biomedical, agricultural, veterinary, food, and cosmetic products. The Journal welcomes fundamental research articles and reports on applications of these microorganisms and substances, and encourages structural studies and studies that correlate the structure and functional properties of antimicrobial proteins.