Rationalizing a prospective coupling effect of cannabinoids with the current pharmacotherapy for melanoma treatment.

IF 4.6 3区 医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL WIREs Mechanisms of Disease Pub Date : 2024-01-01 Epub Date: 2023-11-03 DOI:10.1002/wsbm.1633
Ava Bachari, Nazim Nassar, Ellen Schanknecht, Srinivasareddy Telukutla, Terrence Jerald Piva, Nitin Mantri
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Abstract

Melanoma is one of the leading fatal forms of cancer, yet from a treatment perspective, we have minimal control over its reoccurrence and resistance to current pharmacotherapies. The endocannabinoid system (ECS) has recently been accepted as a multifaceted homeostatic regulator, influencing various physiological processes across different biological compartments, including the skin. This review presents an overview of the pathophysiology of melanoma, current pharmacotherapy used for treatment, and the challenges associated with the different pharmacological approaches. Furthermore, it highlights the utility of cannabinoids as an additive remedy for melanoma by restoring the balance between downregulated immunomodulatory pathways and elevated inflammatory cytokines during chronic skin conditions as one of the suggested critical approaches in treating this immunogenic tumor. This article is categorized under: Cancer > Molecular and Cellular Physiology.

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合理化大麻素与当前黑色素瘤药物治疗的前瞻性耦合效应。
黑色素瘤是癌症的主要致命形式之一,但从治疗的角度来看,我们对其复发和对当前药物疗法的耐药性的控制很小。内源性大麻素系统(ECS)最近被认为是一种多方面的稳态调节因子,影响包括皮肤在内的不同生物区室的各种生理过程。这篇综述概述了黑色素瘤的病理生理学,目前用于治疗的药物治疗,以及与不同药物方法相关的挑战。此外,它强调了大麻素作为黑色素瘤的添加剂疗法的效用,通过在慢性皮肤病期间恢复下调的免疫调节途径和升高的炎性细胞因子之间的平衡,大麻素是治疗这种免疫原性肿瘤的关键方法之一。本文分类为:癌症>分子和细胞生理学。
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来源期刊
WIREs Mechanisms of Disease
WIREs Mechanisms of Disease MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
11.40
自引率
0.00%
发文量
45
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