The Influence of Corn Silk Polysaccharide on Signal Pathway of TGF-β1 in Type 2 Diabetic Mellitus Rat.

Q3 Medicine Open Biomedical Engineering Journal Pub Date : 2015-08-31 eCollection Date: 2015-01-01 DOI:10.2174/1874120701509010204

Xianchun Wen, Liling Yue

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引用次数: 7

Abstract

In prevention stage, comparing with normal control group, triglycerides, blood sugar (BG), 24-hour urinary protein and cholesterol (CHO) were higher in T2DM group, but weight and urea nitrogen (BUN) was less in it. 24-hour urinary protein and cholesterol (CHO) were higher in T2DM group than the intervention group. 24-hour urinary protein and BG in the intervention group were higher than normal control group, but BUN is less than normal control group; In the intervention group the weight of kidney and weight of rat were also higher than T2DM group, but CHO and 24-hour urinary protein were less than T2DM group. The expression of TGF-β1 in T2DM group were more than the other groups. In treatment stage, serum creatinine (Cr), weight, BG and CHO, TGand 24-hour urinary protein quantitative were significantly higher in the DN rats than those in the normal control rats (P>0.05). The expression level of TGF-β1 and triglyceride level in the corn silk dihydroxycorn silk3 treated group were obviously lower than those in the DN rats.

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玉米丝多糖对2型糖尿病大鼠转化生长因子-β1信号通路的影响。

在预防阶段，T2DM组甘油三酯、血糖、24小时尿蛋白和胆固醇（CHO）均高于正常对照组，但体重和尿素氮（BUN）均低于正常对照组。干预组24小时尿蛋白和BG均高于正常对照组，BUN低于正常对照组；干预组大鼠肾重和体重均高于T2DM组，但CHO和24小时尿蛋白均低于T2DM组。TGF-β1在T2DM组的表达明显高于其他各组。在治疗阶段，DN大鼠血清肌酐（Cr）、体重、BG和CHO、TG和24小时尿蛋白定量均显著高于正常对照组（P>0.05）。玉米丝二羟基玉米丝3治疗组TGF-β1和甘油三酯的表达水平明显低于DN大鼠。

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来源期刊

Open Biomedical Engineering Journal Medicine-Medicine (miscellaneous)

CiteScore

1.60

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0.00%

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