Uneven Expression of 20 Human Papillomavirus Genes Associated with Oropharyngeal Carcinoma.

IF 1.4 Q2 MEDICINE, GENERAL & INTERNAL Rambam Maimonides Medical Journal Pub Date : 2023-10-29 DOI:10.5041/RMMJ.10508
Ali Adel Dawood
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Abstract

Background: Human papillomavirus (HPV) is considered to be responsible for 95% of virus-related cancers in many organs. Oropharyngeal carcinoma (OC) is distinguished by the transformation of the healthy epithelium into precancerous cells.

Aim: The current study sought to examine the uneven gene expression of 20 genes among those scanned by microarray for oropharyngeal cancer patients.

Materials and methods: The GSE56142 dataset was extracted from the Gene Expression Omnibus of the National Center for Biotechnology Information; 24 specimens were evaluated. Gene ontology (GO), the Kyoto Encyclopedia of Genes and Genomes, and the protein-protein interaction (PPI) were used to depict the biological roles of the genes under investigation using types of software.

Results: Six genes out of 20 in patients with invasive OC had a binding correlation with high expression (PDGFRS, COL6A3, COL1A1, COL3A1, COL2A1, and COL4A1), and only two genes with low expression (CRCT1 and KRT78). The expression levels of 20 genes were examined for patients with OC versus head and neck squamous cell carcinoma (HNSCC). The correlation coefficient between highly expressed genes of the OC group was statistically significant at the P<0.05 level.

Conclusions: High expression levels of specific genes may serve as diagnostic tumor markers, particularly in the early stages of cancer, and testing should be performed in OC and HNSCC patients.

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20个与口咽癌相关的人乳头瘤病毒基因的不均匀表达。
背景:人类乳头瘤病毒(HPV)被认为是许多器官中95%的病毒相关癌症的原因。口咽癌(OC)的特点是健康上皮转化为癌前细胞。目的:本研究旨在检测癌症患者口咽微阵列扫描的20个基因的不均匀基因表达。材料和方法:GSE56142数据集从国家生物技术信息中心的基因表达综合库中提取;对24个标本进行了评估。基因本体论(GO)、京都基因和基因组百科全书以及蛋白质-蛋白质相互作用(PPI)被用来描述使用各种类型的软件研究的基因的生物学作用。结果:侵袭性OC患者20个基因中有6个与高表达相关(PDGFRS、COL6A3、COL1A1、COL3A1、COL2A1和COL4A1),只有两个基因与低表达相关(CRCT1和KRT78)。检测了OC患者与头颈部鳞状细胞癌(HNSCC)患者20个基因的表达水平。OC组高表达基因之间的相关系数在PC中具有统计学意义。结论:特异性基因的高表达水平可作为诊断肿瘤的标志物,特别是在癌症的早期,应在OC和HNSCC患者中进行检测。
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来源期刊
Rambam Maimonides Medical Journal
Rambam Maimonides Medical Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
6.70%
发文量
55
审稿时长
8 weeks
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