Mitochondrial regulation in stem cells.

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-08-01 Epub Date: 2023-10-31 DOI:10.1016/j.tcb.2023.10.003
Yifei Wang, Marine Barthez, Danica Chen
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Abstract

Stem cells persist throughout the lifespan to repair and regenerate tissues due to their unique ability to self-renew and differentiate. Here we reflect on the recent discoveries in stem cells that highlight a mitochondrial metabolic checkpoint at the restriction point of the stem cell cycle. Mitochondrial activation supports stem cell proliferation and differentiation by providing energy supply and metabolites as signaling molecules. Concomitant mitochondrial stress can lead to loss of stem cell self-renewal and requires the surveillance of various mitochondrial quality control mechanisms. During aging, a mitochondrial protective program mediated by several sirtuins becomes dysregulated and can be targeted to reverse stem cell aging and tissue degeneration, giving hope for targeting the mitochondrial metabolic checkpoint for treating tissue degenerative diseases.

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干细胞中的线粒体调节。
干细胞因其独特的自我更新和分化能力而在整个生命周期中持续存在,以修复和再生组织。在这里,我们回顾了最近在干细胞中的发现,这些发现突出了干细胞周期限制点的线粒体代谢检查点。线粒体激活通过提供能量供应和代谢产物作为信号分子来支持干细胞增殖和分化。伴随的线粒体应激会导致干细胞自我更新的丧失,需要监测各种线粒体质量控制机制。在衰老过程中,由几种sirtuins介导的线粒体保护程序变得失调,可以靶向逆转干细胞衰老和组织变性,为靶向线粒体代谢检查点治疗组织变性疾病带来了希望。
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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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