The Skin Microbiome and Its Role in Psoriasis: A Review.

IF 5.2 Q1 DERMATOLOGY Psoriasis (Auckland, N.Z.) Pub Date : 2023-10-26 eCollection Date: 2023-01-01 DOI:10.2147/PTT.S328439
Valentina Celoria, Francois Rosset, Valentina Pala, Paolo Dapavo, Simone Ribero, Pietro Quaglino, Luca Mastorino
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Abstract

The skin microbiome is made of various microorganisms, most of which have the function of protecting individuals from harmful pathogens, and they are involved in innate and adaptive immune responses. The skin acts as a physical and immunological barrier against external stimuli, including pathogens and physical damage. Changes in the composition of the skin microbiome can trigger inflammatory processes leading to inflammatory skin diseases in susceptible individuals. Psoriasis (PsO) is a chronic inflammatory disease with a multifactorial etiology, where breakdown of immune tolerance to cutaneous microorganisms is implicated in its pathogenesis. Dysregulation of the microbiome due to genetic and environmental factors plays a significant role in the development of psoriatic disease. Dermatologic conditions such as atopic dermatitis, acne, psoriasis, and rosacea have been associated with intestinal dysbiosis. The skin microbiota composition is crucial for the development of appropriate immune responses, and alterations in the skin microbiome can contribute to changes in physiology and susceptibility to skin diseases or inflammatory conditions. Understanding the microbial settlement of the skin and the network of interactions that occur throughout life is essential for comprehending the pathogenesis of skin diseases and developing innovative treatments. With this article we tried to explore the relationship between the human microbiome and psoriatic disease, shedding light on the functions of the microbiome and the inflammatory disease processes to identify additional therapeutic targets. This review aims to highlight the relationship between skin and gut microbiome functions and inflammatory processes in skin psoriasis and psoriatic arthritis (PsA). The goal is to facilitate future studies on the skin microbiome to identify potential novel therapies for patients with psoriatic disease.

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皮肤微生物组及其在银屑病中的作用:综述。
皮肤微生物组由各种微生物组成,其中大多数具有保护个人免受有害病原体侵害的功能,它们参与先天和适应性免疫反应。皮肤是抵御外部刺激的物理和免疫屏障,包括病原体和物理损伤。皮肤微生物组组成的变化会引发炎症过程,导致易感个体的炎症性皮肤病。银屑病(PsO)是一种多因素病因的慢性炎症性疾病,其发病机制与对皮肤微生物免疫耐受的破坏有关。遗传和环境因素导致的微生物组失调在银屑病的发展中起着重要作用。过敏性皮炎、痤疮、牛皮癣和酒渣鼻等皮肤病与肠道生态失调有关。皮肤微生物群的组成对于产生适当的免疫反应至关重要,皮肤微生物组的改变可能会导致生理学的变化以及对皮肤疾病或炎症条件的易感性。了解皮肤的微生物定居和一生中发生的相互作用网络,对于理解皮肤病的发病机制和开发创新的治疗方法至关重要。通过这篇文章,我们试图探索人类微生物组与银屑病之间的关系,揭示微生物组的功能和炎症性疾病过程,以确定其他治疗靶点。这篇综述旨在强调皮肤银屑病和银屑病关节炎(PsA)中皮肤和肠道微生物组功能与炎症过程之间的关系。目标是促进未来对皮肤微生物组的研究,以确定银屑病患者的潜在新疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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