Corilagin attenuates airway inflammation and collagen deposition in ovalbumin-induced asthmatic mice.

IF 2.5 4区医学 Q3 ALLERGY Allergologia et immunopathologia Pub Date : 2023-11-01 eCollection Date: 2023-01-01 DOI:10.15586/aei.v51i6.988

Yan Jin, Chunhua Yi

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引用次数: 0

Abstract

Objective: To investigate the effects of corilagin on inflammation and collagen deposition in ovalbumin (OVA)-induced asthma mouse model and uncover the mechanism.

Methods: We constructed a mouse model of OVA-induced asthma. Enzyme-linked-immunosorbent serologic assays were conducted to detect the effects of corilagin on cytokines and Immunoglobulin E (IgE) production. Hematoxylin and eosin staining was used to show pathological features in lung tissues. Masson trichrome assay was used to examine collagen deposition. In addition, the lung function was detected by mouse lung function apparatus. Immunoblot was used to confirm the mechanism.

Results: Corilagin alleviates OVA-induced cytokine and IgE production. In addition, corilagin alleviates OVA-induced pathological changes and collagen deposition in lung tissues. Corilagin also suppressed airway resistance and lung function in mice. Mechanically, corilagin activated the adenosine monophosphate-activated protein kinase (AMPK) pathway in lung tissues.

Conclusion: Corilagin attenuates airway inflammation and collagen deposition in OVA-induced asthmatic mice via AMPK pathway.

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Corilagin减轻卵清蛋白诱导的哮喘小鼠的气道炎症和胶原沉积。

目的：研究珊瑚苷对卵清蛋白（OVA）诱导的哮喘小鼠模型炎症和胶原沉积的影响，并揭示其作用机制。方法：建立OVA诱导的哮喘小鼠模型。进行酶联免疫吸附血清学测定以检测珊瑚苷对细胞因子和免疫球蛋白E（IgE）产生的影响。苏木精和伊红染色用于显示肺组织的病理特征。Masson三色染色法用于检测胶原沉积。此外，用小鼠肺功能仪检测肺功能。免疫印迹法证实其作用机制。结果：珊瑚苷可减轻OVA诱导的细胞因子和IgE的产生。此外，珊瑚苷可减轻OVA诱导的肺组织病理变化和胶原沉积。Corilagin还能抑制小鼠的气道阻力和肺功能。在机制上，珊瑚苷激活了肺组织中的腺苷酸活化蛋白激酶（AMPK）通路。结论：珊瑚苷通过AMPK途径减轻OVA诱导的哮喘小鼠的气道炎症和胶原沉积。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Allergologia et immunopathologia 医学-过敏

CiteScore

3.70

自引率

0.00%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Founded in 1972 by Professor A. Oehling, Allergologia et Immunopathologia is a forum for those working in the field of pediatric asthma, allergy and immunology. Manuscripts related to clinical, epidemiological and experimental allergy and immunopathology related to childhood will be considered for publication. Allergologia et Immunopathologia is the official journal of the Spanish Society of Pediatric Allergy and Clinical Immunology (SEICAP) and also of the Latin American Society of Immunodeficiencies (LASID). It has and independent international Editorial Committee which submits received papers for peer-reviewing by international experts. The journal accepts original and review articles from all over the world, together with consensus statements from the aforementioned societies. Occasionally, the opinion of an expert on a burning topic is published in the "Point of View" section. Letters to the Editor on previously published papers are welcomed. Allergologia et Immunopathologia publishes 6 issues per year and is included in the major databases such as Pubmed, Scopus, Web of Knowledge, etc.