Novel Strategies for Angiogenesis in Tissue Injury: Therapeutic Effects of iPSCs-Derived Exosomes.

IF 2.6 3区 医学 Q2 PERIPHERAL VASCULAR DISEASE Angiology Pub Date : 2025-01-01 Epub Date: 2023-11-07 DOI:10.1177/00033197231213192
Jiaxin Zhang, Maoning Shi, Jing Wang, Fei Li, Chenxu Du, Gang Su, Xiaodong Xie, Shiweng Li
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Abstract

Regeneration after tissue injury is a dynamic and complex process, and angiogenesis is necessary for normal physiological activities and tissue repair. Induced pluripotent stem cells are a new approach in regenerative medicine, which provides good model for the study of difficult-to-obtain human tissues, patient-specific therapy, and tissue repair. As an innovative cell-free therapeutic strategy, the main advantages of the treatment of induced pluripotent stem cells (iPSCs)-derived exosomes are low in tumorigenicity and immunogenicity, which become an important pathway for tissue injury. This review focuses on the mechanism of the angiogenic effect of iPSCs-derived exosomes on wound repair in tissue injury and their potential therapeutic targets, with a view to providing a theoretical basis for the use of iPSCs-derived exosomes in clinical therapy.

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组织损伤中血管生成的新策略:iPSCs衍生的外泌体的治疗效果。
组织损伤后的再生是一个动态而复杂的过程,血管生成是正常生理活动和组织修复所必需的。诱导多能干细胞是再生医学中的一种新方法,为难以获得的人体组织、患者特异性治疗和组织修复的研究提供了良好的模式。作为一种创新的无细胞治疗策略,诱导多能干细胞(iPSCs)衍生的外泌体治疗的主要优点是具有低致瘤性和免疫原性,这成为组织损伤的重要途径。本文综述了iPSCs来源的外泌体对组织损伤伤口修复的血管生成作用机制及其潜在的治疗靶点,以期为iPSCs衍生的外泌物在临床治疗中的应用提供理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Angiology
Angiology 医学-外周血管病
CiteScore
5.50
自引率
14.30%
发文量
180
审稿时长
6-12 weeks
期刊介绍: A presentation of original, peer-reviewed original articles, review and case reports relative to all phases of all vascular diseases, Angiology (ANG) offers more than a typical cardiology journal. With approximately 1000 pages per year covering diagnostic methods, therapeutic approaches, and clinical and laboratory research, ANG is among the most informative publications in the field of peripheral vascular and cardiovascular diseases. This journal is a member of the Committee on Publication Ethics (COPE). Average time from submission to first decision: 13 days
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