Regulating Striated Muscle Contraction: Through Thick and Thin.

IF 15.7 1区 医学 Q1 PHYSIOLOGY Annual review of physiology Pub Date : 2024-02-12 Epub Date: 2023-11-06 DOI:10.1146/annurev-physiol-042222-022728
Elisabetta Brunello, Luca Fusi
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Abstract

Force generation in striated muscle is primarily controlled by structural changes in the actin-containing thin filaments triggered by an increase in intracellular calcium concentration. However, recent studies have elucidated a new class of regulatory mechanisms, based on the myosin-containing thick filament, that control the strength and speed of contraction by modulating the availability of myosin motors for the interaction with actin. This review summarizes the mechanisms of thin and thick filament activation that regulate the contractility of skeletal and cardiac muscle. A novel dual-filament paradigm of muscle regulation is emerging, in which the dynamics of force generation depends on the coordinated activation of thin and thick filaments. We highlight the interfilament signaling pathways based on titin and myosin-binding protein-C that couple thin and thick filament regulatory mechanisms. This dual-filament regulation mediates the length-dependent activation of cardiac muscle that underlies the control of the cardiac output in each heartbeat.

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调节横纹肌收缩:通过厚和薄。
横纹肌中的力产生主要由细胞内钙浓度增加引发的含有肌动蛋白的细丝的结构变化控制。然而,最近的研究阐明了一类新的调节机制,基于含有肌球蛋白的粗丝,通过调节肌球蛋白马达与肌动蛋白相互作用的可用性来控制收缩的强度和速度。本文综述了细丝和粗丝激活调节骨骼肌和心肌收缩力的机制。一种新的肌肉调节双丝范式正在出现,其中力的产生动力学取决于细丝和粗丝的协调激活。我们强调了基于titin和肌球蛋白结合蛋白-C的丝间信号通路,它们耦合细丝和粗细丝调节机制。这种双丝调节介导心肌的长度依赖性激活,这是每次心跳中心输出量控制的基础。《生理学年度评论》第86卷预计最终在线出版日期为2024年2月。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Annual review of physiology
Annual review of physiology 医学-生理学
CiteScore
35.60
自引率
0.00%
发文量
41
期刊介绍: Since 1939, the Annual Review of Physiology has been highlighting significant developments in animal physiology. The journal covers diverse areas, including cardiovascular physiology, cell physiology, ecological, evolutionary, and comparative physiology, endocrinology, gastrointestinal physiology, neurophysiology, renal and electrolyte physiology, respiratory physiology, and special topics.
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