Process-structure-biofunctional paradigm in cellular structured implants: an overview and perspective on the synergy between additive manufacturing, bio-mechanical behaviour and biological functions.

IF 4.5 3区 生物学 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Artificial Cells, Nanomedicine, and Biotechnology Pub Date : 2023-12-01 Epub Date: 2023-11-07 DOI:10.1080/21691401.2023.2278156
R D K Misra, K P Misra
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Abstract

The overview describes the synergy between biological sciences and cellular structures processed by additive manufacturing to elucidate the significance of cellular structured implants in eliminating stress shielding and in meeting the bio-mechanical property requirements of elastic modulus, impact resistance, and fatigue strength in conjunction with the biological functionality. The convergence of additive manufacturing, computer-aided design, and structure-property relationships is envisaged to provide the solution to the current day challenges in the biomedical arena. The traditional methods of fabrication of biomedical devices including casting and mechanical forming have limitations because of the mismatch in micro/microstructure, mechanical, and physical properties with the host site. Additive manufacturing of cellular structured alloys via electron beam melting and laser powder bed fusion has benefits of fabricating patient-specific design that is obtained from the computed tomography scan of the defect site. The discussion in the overview consists of two aspects - the first one describes the underlying reason that motivated 3D printing of implants from the perspective of minimising stress shielding together with the mechanical property requirements, where the mechanical properties of cellular structured implants depend on the cellular architecture and percentage cellular porosity. The second aspect focuses on the biological response of cellular structured devices.

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细胞结构植入物的过程结构-生物功能范式:增材制造、生物机械行为和生物功能之间协同作用的概述和展望。
概述描述了生物科学和增材制造加工的细胞结构之间的协同作用,以阐明细胞结构植入物在消除应力屏蔽和满足弹性模量、抗冲击性和疲劳强度等生物机械性能要求以及生物功能方面的重要性。增材制造、计算机辅助设计和结构-性能关系的融合有望为当今生物医学领域的挑战提供解决方案。由于微观/微观结构、机械和物理性能与宿主位点不匹配,包括铸造和机械成型在内的生物医学器件的传统制造方法具有局限性。通过电子束熔化和激光粉末床融合的细胞结构合金的增材制造具有制造从缺陷部位的计算机断层扫描获得的患者特定设计的好处。概述中的讨论包括两个方面-第一个方面从最大限度地减少应力屏蔽的角度描述了促使植入物3D打印的根本原因,以及机械性能要求,其中细胞结构植入物的机械性能取决于细胞结构和细胞孔隙率百分比。第二个方面集中于细胞结构设备的生物反应。
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来源期刊
Artificial Cells, Nanomedicine, and Biotechnology
Artificial Cells, Nanomedicine, and Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-ENGINEERING, BIOMEDICAL
CiteScore
10.90
自引率
0.00%
发文量
48
审稿时长
20 weeks
期刊介绍: Artificial Cells, Nanomedicine and Biotechnology covers the frontiers of interdisciplinary research and application, combining artificial cells, nanotechnology, nanobiotechnology, biotechnology, molecular biology, bioencapsulation, novel carriers, stem cells and tissue engineering. Emphasis is on basic research, applied research, and clinical and industrial applications of the following topics:artificial cellsblood substitutes and oxygen therapeuticsnanotechnology, nanobiotecnology, nanomedicinetissue engineeringstem cellsbioencapsulationmicroencapsulation and nanoencapsulationmicroparticles and nanoparticlesliposomescell therapy and gene therapyenzyme therapydrug delivery systemsbiodegradable and biocompatible polymers for scaffolds and carriersbiosensorsimmobilized enzymes and their usesother biotechnological and nanobiotechnological approachesRapid progress in modern research cannot be carried out in isolation and is based on the combined use of the different novel approaches. The interdisciplinary research involving novel approaches, as discussed above, has revolutionized this field resulting in rapid developments. This journal serves to bring these different, modern and futuristic approaches together for the academic, clinical and industrial communities to allow for even greater developments of this highly interdisciplinary area.
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