Iron, Copper, and Selenium: Cancer's Thing for Redox Bling.

IF 7.8 2区 医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Cold Spring Harbor perspectives in medicine Pub Date : 2024-04-01 DOI:10.1101/cshperspect.a041545
Erdem M Terzi, Richard Possemato
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Abstract

Cells require micronutrients for numerous basic functions. Among these, iron, copper, and selenium are particularly critical for redox metabolism, and their importance is heightened during oncogene-driven perturbations in cancer. In this review, which particularly focuses on iron, we describe how these micronutrients are carefully chaperoned about the body and made available to tissues, a process that is designed to limit the toxicity of free iron and copper or by-products of selenium metabolism. We delineate perturbations in iron metabolism and iron-dependent proteins that are observed in cancer, and describe the current approaches being used to target iron metabolism and iron-dependent processes.

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铁、铜和硒:癌症的红细胞闪烁。
细胞需要微量营养素来发挥多种基本功能。其中,铁、铜和硒对氧化还原代谢特别关键,在癌症中,它们在致癌物驱动的扰动中的重要性得到了提高。在这篇特别关注铁的综述中,我们描述了这些微量营养素是如何被小心地陪伴在身体周围并提供给组织的,这一过程旨在限制游离铁和铜或硒代谢副产物的毒性。我们描述了在癌症中观察到的铁代谢和铁依赖性蛋白质的扰动,并描述了目前用于靶向铁代谢和铁依赖性过程的方法。
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来源期刊
Cold Spring Harbor perspectives in medicine
Cold Spring Harbor perspectives in medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
14.30
自引率
1.90%
发文量
44
审稿时长
4-8 weeks
期刊介绍: Cold Spring Harbor Perspectives in Medicine is a monthly online publication comprising reviews on different aspects of a variety of diseases, covering everything from the molecular and cellular bases of disease to translational medicine and new therapeutic strategies. Cold Spring Harbor Perspectives in Medicine is thus unmatched in its depth of coverage and represents an essential source where readers can find informed surveys and critical discussion of advances in molecular medicine.
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