Interleukin-2 gene methylation levels and interleukin-2 levels associated with environmental exposure as risk biomarkers for preterm birth.

IF 1.5 4区医学 Q2 MEDICINE, GENERAL & INTERNAL Croatian Medical Journal Pub Date : 2023-10-31

Aleksandra Fučić, Jelena Knežević, Jure Krasić, Denis Polančec, Nino Sinčić, Nada Sindičić Dessardo, Mirta Starčević, Vedrana Guszak, Marcello Ceppi, Marco Bruzzone

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Abstract

Aim: To compare interleukin-2 levels (IL-2) and IL-2 gene site 1 methylation levels between preterm newborns (PN) and full-term newborns (FN) and investigate their association with the environmental exposure of their mothers during pregnancy.

Methods: IL-2 and IL-2 gene site 1 methylation levels were assessed in 50 PN and 56 FN. Newborns' mothers filled in questionnaires about their living and occupational environments, habits, diets, and hobbies.

Results: The mothers of PN were significantly more frequently agrarian/rural residents than the mothers of FN. PN had significantly higher IL-2 levels, and significantly lower methylation of IL-2 gene site 1 levels than FN.

Conclusion: IL-2 levels, hypomethylation of the IL-2 gene site 1, and the mother's rural residence (probably due to pesticide exposure) were predictive biomarkers for preterm birth. For the first time, we present the reference values for the methylation of IL-2 gene site 1 in PN and FN, which can be used in the clinical setting and biomonitoring.

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白细胞介素-2基因甲基化水平和与环境暴露相关的白细胞介蛋白-2水平是早产的风险生物标志物。

目的：比较早产新生儿（PN）和足月新生儿（FN）白细胞介素2水平（IL-2）和IL-2基因位点1甲基化水平，探讨它们与母亲孕期环境暴露的关系。方法：检测50例PN和56例FN患者的IL-2和IL-2基因位点1甲基化水平。新生儿母亲填写了关于她们的生活和职业环境、习惯、饮食和爱好的问卷。结果：PN的母亲比FN的母亲更经常是农业/农村居民。PN的IL-2水平显著高于FN，IL-2基因位点1甲基化水平显著低于FN。我们首次提出了PN和FN中IL-2基因位点1甲基化的参考值，可用于临床和生物监测。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Croatian Medical Journal 医学-医学：内科

CiteScore

3.00

自引率

5.30%

发文量

105

审稿时长

6-12 weeks

期刊介绍： Croatian Medical Journal (CMJ) is an international peer reviewed journal open to scientists from all fields of biomedicine and health related research. Although CMJ welcomes all contributions that increase and expand on medical knowledge, the two areas are of the special interest: topics globally relevant for biomedicine and health and medicine in developing and emerging countries.