Current strategic trends in drug discovery: the present as prologue.

IF 6 2区 医学 Q1 PHARMACOLOGY & PHARMACY Expert Opinion on Drug Discovery Pub Date : 2024-02-01 DOI:10.1080/17460441.2023.2275640
David R Janero
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Abstract

Introduction: Escalating costs and inherent uncertainties associated with drug discovery invite initiatives to improve its efficiency and de-risk campaigns for inventing better therapeutics. One such initiative involves recognizing and exploiting current approaches in therapeutics invention with molecular mechanisms of action that hold promise for designing and targeting new chemical entities as drugs.

Areas covered: This perspective considers the current contextual framework around three drug-discovery approaches and evaluates their potential to help identify new targets/modalities in small-molecule molecular pharmacology: diversifying ligand-directed phenotypes for G protein-coupled receptor (GPCR) pharmacotherapeutic signaling; developing therapeutic-protein degraders and stabilizers for proximity-inducing pharmacology; and mining organelle biology for druggable therapeutic targets.

Expert opinion: The contemporary drug-discovery approaches examined appear generalizable and versatile to have applications in therapeutics invention beyond those case studies discussed herein. Accordingly, they may be considered strategic trends worthy of note in advancing the field toward novel ways of addressing pharmacotherapeutically unmet medical needs.

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药物发现的当前战略趋势:以现在为开端。
引言:与药物发现相关的成本不断上升和固有的不确定性促使人们采取行动提高其效率,并为发明更好的治疗方法开展风险降低活动。一个这样的倡议涉及认识和利用当前的治疗方法,这些方法具有分子作用机制,有望设计和靶向新的化学实体作为药物。所涵盖的领域:这一观点考虑了目前围绕三种药物发现方法的背景框架,并评估了它们帮助确定小分子分子药理学中新靶点/模式的潜力:G蛋白偶联受体(GPCR)药物治疗信号的配体导向表型多样化;开发用于邻近诱导药理学的治疗性蛋白质降解剂和稳定剂;以及为可药用治疗靶点挖掘细胞器生物学。专家意见:所研究的当代药物发现方法似乎是可推广和通用的,在本文讨论的案例研究之外,在治疗学发明中有应用。因此,它们可能被认为是值得注意的战略趋势,有助于推动该领域以新的方式解决药物治疗未满足的医疗需求。
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来源期刊
CiteScore
10.20
自引率
1.60%
发文量
78
审稿时长
6-12 weeks
期刊介绍: Expert Opinion on Drug Discovery (ISSN 1746-0441 [print], 1746-045X [electronic]) is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles on novel technologies involved in the drug discovery process, leading to new leads and reduced attrition rates. Each article is structured to incorporate the author’s own expert opinion on the scope for future development. The Editors welcome: Reviews covering chemoinformatics; bioinformatics; assay development; novel screening technologies; in vitro/in vivo models; structure-based drug design; systems biology Drug Case Histories examining the steps involved in the preclinical and clinical development of a particular drug The audience consists of scientists and managers in the healthcare and pharmaceutical industry, academic pharmaceutical scientists and other closely related professionals looking to enhance the success of their drug candidates through optimisation at the preclinical level.
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