Discovery of Clinical Manifestations in Spontaneous Glaucoma Suspect Nonhuman Primates.

IF 2 4区 医学 Q2 OPHTHALMOLOGY Ophthalmic Research Pub Date : 2023-01-01 Epub Date: 2023-11-04 DOI:10.1159/000533865
Xu Jia, Ziyu Yu, Jian Wu, Simeng Hou, Yifan Du, Yingting Zhu, Zhidong Li, Shu Tu, Ling Zhao, Wenru Su, Ningli Wang, Yehong Zhuo
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Abstract

Introduction: The primary aim of this study was to assess the longitudinal changes in retinal nerve fiber layer (RNFL) thickness and relative ONH parameters using spectral-domain optical coherence tomography (SD-OCT) in the living eyes of nonhuman primates with spontaneous glaucoma.

Methods: Totally 9 macaque subjects underwent a standard fundus photo and OCT examination, including 3 adult monkeys with stable elevated intraocular pressure (IOP) as the glaucoma suspect group and 6 normal IOP monkeys as the control group. Each eye of primates with IOP measurement was repeated three times. OCT measurements recorded RNFL, Bruch's membrane opening (BMO) minimum rim width (MRW). The follow-up scan of glaucomatous subjects was undergone in 10 months.

Results: The mean ages of glaucoma and healthy subjects are 19.33 ± 0.33 and 20.5 ± 1.46 years. Elevated IOP was achieved in three nonhuman primate eyes with an average increase of 10 mm Hg over the study period. Elevated IOP was associated with decreased RNFL thickness in all the regions and decreased RNFL phase retardation in the superior and inferior regions. When averaged over the entire retinal area, only the whole RNFL and temporal regions showed a significant decrease. The mean IPL thicknesses are 87.17 ± 2.15 μm in glaucomatous and 93.33 ± 1.51 μm in healthy eyes (p = 0.03). Lamina cribrosa parameters are measured from the OCT images and showed significant differences between glaucoma primates and normal primates.

Conclusions: Of the measured parameters, decreased RNFL and MRW were correlated with glaucomatous damage. Natural glaucoma primate can be a natural glaucoma model which is closer to glaucoma in humans.

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发现自发性青光眼的临床表现怀疑是非人类灵长类动物。
引言:本研究的主要目的是使用光谱域光学相干断层扫描(SD-OCT)评估患有自发性青光眼的非人类灵长类动物活体眼睛中RNFL厚度和相对ONH参数的纵向变化。方法:对9只猕猴进行标准眼底及OCT检查,其中3只眼压稳定升高的成年猴为青光眼可疑组,6只眼压正常猴为对照组。灵长类动物的每只眼睛都重复进行三次IOP测量。OCT测量记录了视网膜神经纤维层厚度(RNFL)、布鲁赫膜开口(BMO)最小边缘宽度(MRW)。青光眼受试者在10个月内进行了随访扫描。结果:青光眼患者和健康人的平均年龄分别为19.33±0.33和20.5±1.46岁。在研究期间,三只非人类灵长类动物眼睛的眼压升高,平均增加了10毫米汞柱。IOP升高与所有区域的RNFL厚度降低以及上下区域RNFL相位延迟降低有关。当在整个视网膜区域进行平均时,只有整个RNFL和颞叶区域显示出显著下降。青光眼患者的平均IPL厚度为87.17±2.15μm,健康眼为93.33±1.51μm(P=0.03)。根据OCT图像测量的筛状层参数显示,青光眼灵长类动物和正常灵长类动物之间存在显著差异。结论:在测量的参数中,RNFL和MRW的降低与青光眼损伤有关。自然青光眼灵长类动物可以是一种更接近人类青光眼的自然青光眼模型。
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来源期刊
Ophthalmic Research
Ophthalmic Research 医学-眼科学
CiteScore
3.80
自引率
4.80%
发文量
75
审稿时长
6-12 weeks
期刊介绍: ''Ophthalmic Research'' features original papers and reviews reporting on translational and clinical studies. Authors from throughout the world cover research topics on every field in connection with physical, physiologic, pharmacological, biochemical and molecular biological aspects of ophthalmology. This journal also aims to provide a record of international clinical research for both researchers and clinicians in ophthalmology. Finally, the transfer of information from fundamental research to clinical research and clinical practice is particularly welcome.
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