Nanoemulsion: An Emerging Novel Technology for Improving the Bioavailability of Drugs.

IF 2.3 Q2 BIOLOGY Scientifica Pub Date : 2023-10-28 eCollection Date: 2023-01-01 DOI:10.1155/2023/6640103
Preeti, Sharda Sambhakar, Rohit Malik, Saurabh Bhatia, Ahmed Al Harrasi, Chanchal Rani, Renu Saharan, Suresh Kumar, Geeta, Renu Sehrawat
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Abstract

The pharmaceutical sector has made considerable strides recently, emphasizing improving drug delivery methods to increase the bioavailability of various drugs. When used as a medication delivery method, nanoemulsions have multiple benefits. Their small droplet size, which is generally between 20 and 200 nanometers, creates a significant interfacial area for drug dissolution, improving the solubility and bioavailability of drugs that are weakly water-soluble. Additionally, nanoemulsions are a flexible platform for drug administration across various therapeutic areas since they can encapsulate hydrophilic and hydrophobic medicines. Nanoemulsion can be formulated in multiple dosage forms, for example, gels, creams, foams, aerosols, and sprays by using low-cost standard operative processes and also be taken orally, topically, topically, intravenously, intrapulmonary, intranasally, and intraocularly. The article explores nanoemulsion formulation and production methods, emphasizing the role of surfactants and cosurfactants in creating stable formulations. In order to customize nanoemulsions to particular medication delivery requirements, the choice of components and production techniques is crucial in assuring the stability and efficacy of the finished product. Nanoemulsions are a cutting-edge technology with a lot of potential for improving medication bioavailability in a variety of therapeutic contexts. They are a useful tool in the creation of innovative pharmaceutical formulations due to their capacity to enhance drug solubility, stability, and delivery. Nanoemulsions are positioned to play a crucial role in boosting medication delivery and enhancing patient outcomes as this field of study continues to advance.

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纳米乳液:一种新兴的提高药物生物利用度的新技术。
制药部门最近取得了长足的进步,强调改进药物递送方法,以提高各种药物的生物利用度。当用作药物递送方法时,纳米乳液具有多种益处。它们的小液滴尺寸,通常在20到200之间 纳米,为药物溶解创造了显著的界面区域,提高了弱水溶性药物的溶解度和生物利用度。此外,纳米乳液是一个灵活的平台,用于各种治疗领域的药物管理,因为它们可以包裹亲水性和疏水性药物。纳米乳液可以通过低成本的标准操作过程配制成多种剂型,例如凝胶、乳膏、泡沫、气雾剂和喷雾剂,也可以口服、局部、局部、静脉内、肺内、鼻内和口内服用。本文探讨了纳米乳液的配方和生产方法,强调了表面活性剂和助表面活性剂在创造稳定配方中的作用。为了根据特定的药物输送要求定制纳米乳液,成分和生产技术的选择对于确保成品的稳定性和功效至关重要。纳米乳液是一种尖端技术,在各种治疗环境中具有提高药物生物利用度的巨大潜力。它们是创造创新药物配方的有用工具,因为它们能够提高药物的溶解度、稳定性和递送能力。随着这一研究领域的不断发展,纳米乳液在促进药物输送和提高患者预后方面发挥着至关重要的作用。
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来源期刊
Scientifica
Scientifica BIOLOGY-
CiteScore
6.70
自引率
0.00%
发文量
43
审稿时长
21 weeks
期刊介绍: Scientifica is a peer-reviewed, Open Access journal that publishes research articles, review articles, and clinical studies covering a wide range of subjects in the life sciences, environmental sciences, health sciences, and medicine. The journal is divided into the 65 subject areas.
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