Circulating lung cancer biomarkers: From translational research to clinical practice.

Q3 Biochemistry, Genetics and Molecular Biology Tumor Biology Pub Date : 2024-01-01 DOI:10.3233/TUB-230012

Xu Qian, Qing-He Meng

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Abstract

Fundamental studies on biomarkers as well as developed assays for their detection can provide valuable information facilitating clinical decisions. For patients with lung cancer, there are established circulating biomarkers such as serum progastrin-releasing peptide (ProGRP), neuron-specific enolase (NSE), squamous cell carcinoma antigen (SCC-Ag), carcinoembryonic antigen (CEA), and cytokeratin-19 fragment (CYFRA21-1). There are also molecular biomarkers for targeted therapy such as epidermal growth factor receptor (EGFR) gene, anaplastic lymphoma kinase (ALK) gene, KRAS gene, and BRAF gene. However, there is still an unmet need for biomarkers that can be used for early detection and predict treatment response and survival. In this review, we describe the lung cancer biomarkers that are currently being used in clinical practice. We also discuss emerging preclinical and clinical studies on new biomarkers such as omics-based biomarkers for their potential clinical use to detect, predict, or monitor subtypes of lung cancer. Additionally, between-method differences in tumor markers warrant further development and improvement of the standardization and harmonization for each assay.

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循环肺癌癌症生物标志物：从转化研究到临床实践。

生物标志物的基础研究以及开发的检测方法可以为临床决策提供有价值的信息。对于癌症患者，已经建立了循环生物标志物，如血清前胃泌素释放肽（ProGRP）、神经元特异性烯醇化酶（NSE）、鳞状细胞癌抗原（SCC-Ag）、癌胚抗原（CEA）和细胞角蛋白-19片段（CYFRA21-1）。还有用于靶向治疗的分子生物标志物，如表皮生长因子受体（EGFR）基因、间变性淋巴瘤激酶（ALK）基因、KRAS基因和BRAF基因。然而，对可用于早期检测和预测治疗反应和存活率的生物标志物的需求仍然没有得到满足。在这篇综述中，我们描述了目前在临床实践中使用的癌症生物标志物。我们还讨论了新生物标志物的临床前和临床研究，如基于组学的生物标志物，用于检测、预测或监测癌症亚型的潜在临床应用。此外，肿瘤标志物的方法间差异保证了每种测定的标准化和协调性的进一步发展和改进。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tumor Biology 医学-肿瘤学

CiteScore

5.40

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： Tumor Biology is a peer reviewed, international journal providing an open access forum for experimental and clinical cancer research. Tumor Biology covers all aspects of tumor markers, molecular biomarkers, tumor targeting, and mechanisms of tumor development and progression. Specific topics of interest include, but are not limited to: Pathway analyses, Non-coding RNAs, Circulating tumor cells, Liquid biopsies, Exosomes, Epigenetics, Cancer stem cells, Tumor immunology and immunotherapy, Tumor microenvironment, Targeted therapies, Therapy resistance Cancer genetics, Cancer risk screening. Studies in other areas of basic, clinical and translational cancer research are also considered in order to promote connections and discoveries across different disciplines. The journal publishes original articles, reviews, commentaries and guidelines on tumor marker use. All submissions are subject to rigorous peer review and are selected on the basis of whether the research is sound and deserves publication. Tumor Biology is the Official Journal of the International Society of Oncology and BioMarkers (ISOBM).