rs217727 of lncRNA H19 is Associated with Cervical Cancer Risk in the Chinese Han Population.

IF 1.8 4区医学 Q3 PHARMACOLOGY & PHARMACY Pharmacogenomics & Personalized Medicine Pub Date : 2023-10-30 eCollection Date: 2023-01-01 DOI:10.2147/PGPM.S422083

Jie Dai, Shao Zhang, Yuhan Shi, Jinmei Xu, Weipeng Liu, Jia Yang, Li Shi, Zhiling Yan, Chuanyin Li

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Abstract

Background: Long noncoding RNAs (LncRNAs) have been revealed to involve in cervical cancer (CC) developing. The current study was designed to explore the association of SNPs (rs217727, rs2366152, rs1859168, rs10505477) located in the lncRNA H19, HOTAIR, HOTTIP and CASC8 genes with the risk of CC in a Chinese Han population.

Methods: Four SNPs were selected and genotyped in 1426 participants (274 CIN patients, 448 CC patients, and 704 healthy control individuals) using MassArray. The association of these SNPs with susceptibility to CC was evaluated.

Results: Significant differences in allelic distribution of rs217727 were observed in the comparison of CC with control (P = 0.001), indicating the risk of rs217727-A allele in CC (OR = 1.33; 95% CI: 1.12-1.58). The inheritance model analysis revealed that 2AA+GA genotype represented a certain risk of CC (P = 0.001, OR = 1.35; 95% CI: 1.13-1.62). The stratified analysis revealed a risk of the rs217727-A allele for cervical squamous cell carcinoma (SCC) (P = 0.002, OR = 1.33; 95% CI: 1.11-1.60).

Conclusion: rs217727 in lncRNA H19 exhibited a significant correlation with CC susceptibility, particularly SCC, and A/A genotype of this SNP might present as a risk in CC.

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lncRNA H19的rs217727与中国汉族人群宫颈癌症风险相关。

背景：长链非编码RNA（LncRNA）已被发现参与宫颈癌症（CC）的发展。本研究旨在探讨中国汉族人群中位于lncRNA H19、HOTIAR、HOTTIP和CASC8基因中的SNPs（rs217727、rs2366152、rs1859168、rs10505477）与CC风险的关系。方法：使用MassArray在1426名参与者（274名CIN患者、448名CC患者和704名健康对照者）中选择4个SNP并进行基因分型。评估了这些SNPs与CC易感性的相关性。结果：CC与对照组rs217727等位基因分布差异有统计学意义（P=0.001），表明rs217727-A等位基因在CC中的风险（OR=1.33；95%CI:1.12-1.58）。遗传模型分析显示2AA+GA基因型代表一定的CC风险（P=0.001，OR=1.35；95%CI:1.13-1.62）。分层分析显示rs217727-A等位基因对宫颈鳞状细胞癌（SCC）的风险（P=0.002，OR=1.33，95%CI:1.11-1.60）。结论：lncRNA中的rs217727H19表现出与CC易感性，特别是SCC的显著相关性，并且该SNP的a/a基因型可能是CC的风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacogenomics & Personalized Medicine Biochemistry, Genetics and Molecular Biology-Molecular Medicine

CiteScore

3.30

自引率

5.30%

发文量

110

审稿时长

16 weeks

期刊介绍： Pharmacogenomics and Personalized Medicine is an international, peer-reviewed, open-access journal characterizing the influence of genotype on pharmacology leading to the development of personalized treatment programs and individualized drug selection for improved safety, efficacy and sustainability. In particular, emphasis will be given to: Genomic and proteomic profiling Genetics and drug metabolism Targeted drug identification and discovery Optimizing drug selection & dosage based on patient''s genetic profile Drug related morbidity & mortality intervention Advanced disease screening and targeted therapeutic intervention Genetic based vaccine development Patient satisfaction and preference Health economic evaluations Practical and organizational issues in the development and implementation of personalized medicine programs.