CT-based evaluation of tissue expansion in cryoablation of ex vivo kidney.

Biomedizinische Technik. Biomedical engineering Pub Date : 2023-11-06 Print Date: 2024-04-25 DOI:10.1515/bmt-2023-0174

Frank Hübner, Moritz Klaus, Norbert Siedow, Christian Leithäuser, Thomas Josef Vogl

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Abstract

Objectives: To evaluate tissue expansion during cryoablation, the displacement of markers in ex vivo kidney tissue was determined using computed tomographic (CT) imaging.

Methods: CT-guided cryoablation was performed in nine porcine kidneys over a 10 min period. Markers and fiber optic temperature probes were positioned perpendicular to the cryoprobe shaft in an axial orientation. The temperature measurement was performed simultaneously with the acquisitions of the CT images in 5 s intervals. The distance change of the markers to the cryoprobe was determined in each CT image and equated to the measured temperature at the marker.

Results: The greatest increase in the distance between the markers and the cryoprobe was observed in the initial phase of cryoablation. The maximum displacement of the markers was determined to be 0.31±0.2 mm and 2.8±0.02 %, respectively.

Conclusions: The mean expansion of ex vivo kidney tissue during cryoablation with a single cryoprobe is 0.31±0.2 mm. The results can be used for identification of basic parameters for optimization of therapy planning.

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离体肾脏冷冻消融中组织扩张的CT评价。

目的：为了评估冷冻消融过程中的组织扩张，使用计算机断层成像（CT）确定离体肾组织中标记物的位移。方法：在10年的时间里，对9个猪肾脏进行了CT引导下的冷冻消融 最小周期。标记物和光纤温度探针在轴向方向上垂直于冷冻探针轴定位。温度测量与5中CT图像的采集同时进行 s间隔。在每个CT图像中确定标记物到冷冻探针的距离变化，并将其等同于标记物处的测量温度。结果：在冷冻消融的初始阶段，观察到标记物与冷冻探针之间的距离增加最大。标记物的最大位移确定为0.31±0.2 mm和2.8±0.02 %, 分别地结论：单个冷冻探针冷冻消融过程中离体肾组织的平均膨胀为0.31±0.2 该结果可用于识别用于优化治疗计划的基本参数。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Biomedizinische Technik. Biomedical engineering

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