A polyhexamethylene biguanide-assembly assisted strategy of dentin bonding greatly promotes bonding effects and caries treatment†

IF 6.1 3区 医学 Q1 MATERIALS SCIENCE, BIOMATERIALS Journal of Materials Chemistry B Pub Date : 2023-10-25 DOI:10.1039/D3TB02083E
Chang Shu, Yadong Chen, Zhenzhen Zhang, Yuqing Lei, Jiajia Xu, Weiwei Lao, Qingping Xi, Qiang Sun, Xiaojun Li, Hongbing Liao, Qiaojie Luo and Xiaodong Li
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Abstract

Structural degeneration of a hybrid layer composed of a demineralized dentin matrix (DDM) and adhesive causes unsatisfactory functional outcomes in terms of bonding repair and caries treatment and is accompanied by high prevalence of secondary caries. Clinically, defects in the hybrid layer from insufficient adhesive infiltration, bacterial load from retained infected-dentin, and bacterial attack from the oral cavity are the main threats to degeneration. Currently, there is no strategy to simultaneously address adhesive penetration and bacterial infection. Herein, based on the core role of the strongly-polar hydrated DDM interface in dentin bonding, an interface-reconstructed bonding strategy assisted by electrostatic assembly of broad-spectrum germicidal polyhexamethylene biguanide (PHMB) is proposed that kills two birds with one stone. PHMB is absorbed onto the anionic 3D DDM forming a PHMB/DDM complex. The surface potential of the DDM increases by about 100 mV, the anion content decreases by 20%, and the interface water content decreases by nearly 40%. All of these changes contribute to the penetration of the adhesive, thereby improving the bonding strength and durability. After thermal cycling aging, the bonding strength of the PHMB group was 1.45–1.65 times that of the control group. In terms of antibacterial properties, PHMB treatment not only has a bacterial-killing ability due to the already formed biofilm but also significantly reduces the adhesion of bacteria, thereby delaying the occurrence of secondary caries. In summary, PHMB treatment reconstructed the DDM interface, resulting in a defect-low and inherent antibacterial hybrid layer that improves the bonding effect, treatment of caries and even prevention of secondary caries.

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聚六亚甲基双胍组装辅助的牙本质结合策略极大地促进了结合效果和龋齿治疗。
由脱矿牙本质基质(DDM)和粘合剂组成的混合层的结构退化导致结合修复和龋齿治疗方面的功能结果不令人满意,并伴有继发性龋齿的高患病率。临床上,由于粘合剂渗透不足导致的混合层缺陷、残留的感染牙本质产生的细菌负荷以及口腔细菌攻击是退化的主要威胁。目前,还没有同时解决粘合剂渗透和细菌感染的策略。本文基于强极性水合DDM界面在牙本质结合中的核心作用,提出了一种由广谱杀菌聚六亚甲基双胍(PHMB)静电组装辅助的界面重建结合策略,一举两得。PHMB被吸收到阴离子3DDDM上,形成PHMB/DDM复合物。DDM的表面电势增加了约100mV,阴离子含量减少了20%,界面水含量减少了近40%。所有这些变化都有助于粘合剂的渗透,从而提高粘合强度和耐久性。热循环老化后,PHMB组的结合强度是对照组的1.45-1.65倍。就抗菌性能而言,PHMB治疗不仅由于已经形成的生物膜而具有杀菌能力,而且显著降低了细菌的粘附性,从而延缓了继发龋的发生。总之,PHMB处理重建了DDM界面,形成了一层低缺陷的固有抗菌混合层,提高了粘结效果、治疗龋齿甚至预防继发龋。
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来源期刊
Journal of Materials Chemistry B
Journal of Materials Chemistry B MATERIALS SCIENCE, BIOMATERIALS-
CiteScore
11.50
自引率
4.30%
发文量
866
期刊介绍: Journal of Materials Chemistry A, B & C cover high quality studies across all fields of materials chemistry. The journals focus on those theoretical or experimental studies that report new understanding, applications, properties and synthesis of materials. Journal of Materials Chemistry A, B & C are separated by the intended application of the material studied. Broadly, applications in energy and sustainability are of interest to Journal of Materials Chemistry A, applications in biology and medicine are of interest to Journal of Materials Chemistry B, and applications in optical, magnetic and electronic devices are of interest to Journal of Materials Chemistry C.Journal of Materials Chemistry B is a Transformative Journal and Plan S compliant. Example topic areas within the scope of Journal of Materials Chemistry B are listed below. This list is neither exhaustive nor exclusive: Antifouling coatings Biocompatible materials Bioelectronics Bioimaging Biomimetics Biomineralisation Bionics Biosensors Diagnostics Drug delivery Gene delivery Immunobiology Nanomedicine Regenerative medicine & Tissue engineering Scaffolds Soft robotics Stem cells Therapeutic devices
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