Catalyst-free electroreductive carboxylic acid–nitroarene coupling†

Abstract

The concept of electrosynthesis, which enables single electron reduction without relying on expensive catalysts, has captivated the attention of both academic and industrial researchers. In our pioneering work, we delve into the realm of this promising methodology by presenting a remarkable application of the cross-coupling of redox-active esters with nitroarenes utilizing sacrificial metal anodes. This innovative approach empowers the synthesis of high-value products from readily available and economically viable starting materials. By harnessing the power of electrosynthesis, we not only achieve efficient transformations but also contribute to the sustainability and accessibility of valuable chemical synthesis.