Subclinical neural hearing alterations in school children with type 1 diabetes mellitus

Abstract

Background and objectives

Evidence has shown a cause-and-effect relationship between type 1 diabetes mellitus and auditory and cognitive dysfunctions. This study aimed to investigate the effect of type 1 diabetes mellitus (T1DM) on central auditory and cognitive functions in school-age children and adolescents.

Methods

The study sample consisted of 101 children and adolescents, 50 with T1DM, of both sexes, aged between 7 and 18 years. All participants were selected for a structured interview on hearing, behavioral, and cognitive health and assessment of brainstem auditory evoked potentials (BAEP) and event-related potentials (P300).

Results

Significant differences were observed in memory (p = 0.002) and attention (p = 0.021) complaints between participants with and without T1DM. In the BAEP responses, there were differences between wave III latencies in the right (p = 0.017) and left (p = 0.019) ears and in wave V latencies in the left ear (p = 0.001) between the evaluated groups. In addition, there was an association between BAEP findings and metabolic control in the T1DM group in the left ear in waves III (p = 0.006) and V (p = 0.005) and in the right ear in wave V (p = 0.026). No differences were observed in the latencies of P300 between the evaluated groups.

Conclusion

This study demonstrated the existence of a subclinical finding in the central auditory pathway, offering an increased risk for retrocollear alterations, which may be a consequence of poor metabolic control.