Molecular distribution of allotypic determinants Lpm7 and Lpm8 of mink very high density α2-lipoprotein

Abstract

Agar gel double-diffusion experiments demonstrated that the allodeterminants Lpm7 and Lpm8, very high density lipoproteins of mink, reside on different molecules. Molecules possessing Lpm7 and Lpm8 have no other known Lpm-allodeterminants. These results extend our earlier observations on the distribution of Lpm1, Lpm2, Lpm3, Lpm4 and Lpm5 on lipoprotein molecules. It is concluded that Lpm-lipoproteins from mink sera are represented by molecules of several types. identical in their species-specific antigenic properties and each having a unique allodeterminant. The distribution patterns of Lpm7 and Lpm8 among molecules support the suggestion that monogenically inherited allogroups are controlled by closely-linked structural genes.