Immunochemical studies on blood groups-LXVIII

Abstract

Oligosaccharide inhibition studies using anti-I Ma (group 1) showed thatdGalβl → 4dGlcNAcβl → 6dGal its βl → O-(CH₂)₈COOCH₃ glycoside and OGR_L1.1 (dGalβl → 4dGlcNAcβl → 6-3,4-dideoxy-hex-3-enitols) were equally active on a molar basis defining the anti-I Ma (group 1) site as complementary todGalβl → 4dGlcNAcβl → OCH₂-. The 1 → 3,1 → 6 compound showed very weak activity, the 1 → 4.1 → 3 and 1 → 3.1 → 3 compounds and the βl → O-(CH₂)₈COOCH₃ glycosides of these three latter compounds were inactive in the range studied. The anti-S XIV site differs from the anti-I Ma site in thatdGalβl → 4dGlcNAcβl → 6dGal was only slightly better thandGalβl → 4dGlcNAcβl → 3dGal and both were only about 1–3 more active thandGalβl → 4dGlcNAc. All compounds were inactive in the amounts available (1–2 μM) with anti-I Step and Nay (group 3), Phi and AJ (group 6) and anti-i Den.