The status of Helicobacter pylori infection related extraintestinal diseases in Myanmar

Abstract

Background

Myanmar is the country where the prevalence of Helicobacter pylori (H. pylori) infection is high among Southeast Asia region. Many studies have demonstrated association of H. pylori infection with extraintestinal diseases as in pathogenic role.

Methods

This is narrative review article. Available studies regarding H. pylori and extraintestinal manifestations; both full texts and abstracts which appeared in the Union catalogue of Myanmar Health science link, were reviewed in this article.

Results

There were statistically significant association between H. pyloriinfection and autoimmune thrombocytopenia (P = .001), coronary artery disease (P = .001), Parkinson’s diseases (P = .001), chronic urticaria (P = .007) and psoriasis (P = .001). There were trend towards positive association with H. pylori infection and type 2 diabetes mellitus (0.544), ischemic stroke (P = .163) and pemphigus (58%) although statistically did not significant.

Conclusion

This is the first paper in Myanmar reviewing the prevalence of extraintestinal manifestation of H. pylori infection in Myanmar. Although the majority are descriptive in design and the results were heterogeneous , there are trend towards positive association of H. pylori infection and extraintestinal diseases in Myanmar.