Assessment of prognostic biomarkers in sudden sensorineural hearing loss: A systematic review and meta-analysis

IF 2.5 3区医学 Q2 MEDICAL LABORATORY TECHNOLOGY Clinical biochemistry Pub Date : 2023-11-01 DOI:10.1016/j.clinbiochem.2023.110684

Somayeh Niknazar , Narges Bazgir , Vahideh Shafaei , Hojjat-Allah Abbaszadeh , Alireza Zali , Ali Asghar Peyvandi

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Abstract

Sudden sensorineural hearing loss (SSNHL) is defined as hearing loss of more than 30 dB in less than 72 h. SSNHL is a frequent complaint and an emergency in otolaryngology. Various biomarkers have been used to determine the prognosis of SSNHL. This systematic review and meta-analysis aims to evaluate the relationship between the different biomarkers and the prognosis of SSNHL. We searched English-language literature up to October 2022 in four databases, including PubMed, Google Scholar, Cochrane, and Science Direct. This search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. This study was reported in the International Prospective Register of Systematic Reviews (PROSPERO) database (ID = CRD42022369538). All studies examining the role of neutrophil to lymphocyte ratio (NLR) concluded that higher NLR is associated with a worse prognosis. The results of studies regarding the relationship between platelet to lymphocyte ratio (PLR) and tumor necrosis factor (TNF) are controversial. Other factors shown to be associated with SSNHL include Glycated hemoglobin (HbA1C), blood glucose, iron levels, serum endocan, salusin-beta, and bone turnover biomarkers. This meta-analysis showed that PLR, NLR, and neutrophils were significantly different between recovered and non-recovered patients. PLR, NLR, and neutrophil count are reliable tools to assess the prognosis of patients with SSNHL.

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突发性感音神经性听力损失预后生物标志物的评估：一项系统综述和荟萃分析。

突发性感音神经性听力损失（SSNHL）被定义为听力损失超过30 dB小于72 h.SSNHL是耳鼻喉科的常见病和急诊。各种生物标志物已被用于确定SSNHL的预后。本系统综述和荟萃分析旨在评估不同生物标志物与SSNHL预后之间的关系。我们在PubMed、Google Scholar、Cochrane和Science Direct等四个数据库中搜索了截至2022年10月的英语文献。这项搜索是根据系统评价和荟萃分析的首选报告项目（PRISMA）声明进行的。这项研究发表在国际前瞻性系统评价登记册（PROSPERO）数据库（ID = CRD42022369538）。所有研究中性粒细胞与淋巴细胞比率（NLR）的作用都得出结论，NLR越高预后越差。关于血小板与淋巴细胞比率（PLR）和肿瘤坏死因子（TNF）之间关系的研究结果存在争议。其他显示与SSNHL相关的因素包括糖化血红蛋白（HbA1C）、血糖、铁水平、血清内皮素、salusinβ和骨转换生物标志物。该荟萃分析显示，PLR、NLR和中性粒细胞在康复患者和未康复患者之间存在显著差异。PLR、NLR和中性粒细胞计数是评估SSNHL患者预后的可靠工具。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical biochemistry 医学-医学实验技术

CiteScore

5.10

自引率

0.00%

发文量

151

审稿时长

25 days

期刊介绍： Clinical Biochemistry publishes articles relating to clinical chemistry, molecular biology and genetics, therapeutic drug monitoring and toxicology, laboratory immunology and laboratory medicine in general, with the focus on analytical and clinical investigation of laboratory tests in humans used for diagnosis, prognosis, treatment and therapy, and monitoring of disease.