The vascular complications of diabetes: a review of their management, pathogenesis, and prevention.

IF 2.7 Q3 ENDOCRINOLOGY & METABOLISM Expert Review of Endocrinology & Metabolism Pub Date : 2024-01-01 DOI:10.1080/17446651.2023.2279533

Juliet Meir, Lillian Huang, Sumaita Mahmood, Harris Whiteson, Scott Cohen, Wilbert S Aronow

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Abstract

Introduction: This review highlights the pathogenesis of both microvascular and macrovascular complications of diabetes and how these mechanisms influence both the management and preventative strategies of these complications. The cumulative data shown in this review suggest hyperglycemic and blood pressure control remain central to this intricate process.

Areas covered: We reviewed the literature including retrospective, prospective trials as well as meta-analysis, and post hoc analysis of randomized trials on microvascular andmacrovascular complications.

Expert opinion: Further research is needed to explore the ideal intervention targets and preventative strategies needed to prevent macrovascular complications. Furthermore, as the data for trials looking at microvascular complications lengthen more long-term data will further elucidate the role that the duration of diabetes has on these complications. Additionally, trials looking to maximize hyperglycemic control with multiple agents in diabetes, such as metformin, SGL2isand GLP-1 receptor agonists are currently in process, which will have implications for rates of microvascular as well as macrovascular complications.

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糖尿病的血管并发症：管理、发病机制和预防综述。

引言：这篇综述强调了糖尿病微血管和大血管并发症的发病机制，以及这些机制如何影响这些并发症的管理和预防策略。这篇综述中显示的累积数据表明，高血糖和血压控制仍然是这一复杂过程的核心。涵盖领域：我们回顾了文献，包括回顾性、前瞻性试验、荟萃分析和微血管和大血管并发症随机试验的事后分析。专家意见：需要进一步研究，以探索预防大血管并发症所需的理想干预目标和预防策略。此外，随着研究微血管并发症的试验数据的延长，更多的长期数据将进一步阐明糖尿病持续时间对这些并发症的作用。此外，目前正在进行多种药物（如二甲双胍、SGL2isa和GLP-1受体激动剂）最大限度地控制糖尿病高血糖的试验，这将对微血管和大血管并发症的发生率产生影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Expert Review of Endocrinology & Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

4.80

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0.00%

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期刊介绍： Implicated in a plethora of regulatory dysfunctions involving growth and development, metabolism, electrolyte balances and reproduction, endocrine disruption is one of the highest priority research topics in the world. As a result, we are now in a position to better detect, characterize and overcome the damage mediated by adverse interaction with the endocrine system. Expert Review of Endocrinology and Metabolism (ISSN 1744-6651), provides extensive coverage of state-of-the-art research and clinical advancements in the field of endocrine control and metabolism, with a focus on screening, prevention, diagnostics, existing and novel therapeutics, as well as related molecular genetics, pathophysiology and epidemiology.