TGF-β, EMT, and resistance to anti-cancer treatment

IF 12.1 1区医学 Q1 ONCOLOGY Seminars in cancer biology Pub Date : 2023-11-08 DOI:10.1016/j.semcancer.2023.10.004

Xuecong Wang , Pieter Johan Adam Eichhorn , Jean Paul Thiery

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Abstract

Transforming growth factor-β (TGF-β) signaling regulates cell-specific programs involved in embryonic development, wound-healing, and immune homeostasis. Yet, during tumor progression, these TGF-β-mediated programs are altered, leading to epithelial cell plasticity and a reprogramming of epithelial cells into mesenchymal lineages through epithelial-to-mesenchymal transition (EMT), a critical developmental program in morphogenesis and organogenesis. These changes, in turn, lead to enhanced carcinoma cell invasion, metastasis, immune cell differentiation, immune evasion, and chemotherapy resistance. Here, we discuss EMT as one of the critical programs associated with carcinoma cell plasticity and the influence exerted by TGF-β on carcinoma status and function. We further explore the composition of carcinoma and other cell populations within the tumor microenvironment, and consider the relevant outcomes related to the programs associated with cancer treatment resistance.

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转化生长因子-β、EMT和抗癌治疗的耐药性。

转化生长因子-β（TGF-β）信号调节参与胚胎发育、伤口愈合和免疫稳态的细胞特异性程序。然而，在肿瘤进展过程中，这些TGF-β介导的程序发生了改变，导致上皮细胞的可塑性，并通过上皮-间充质转化（EMT）将上皮细胞重新编程为间充质谱系，这是形态发生和器官发生中的一个关键发育程序。这些变化反过来又导致癌细胞侵袭、转移、免疫细胞分化、免疫逃避和化疗耐药性增强。在此，我们讨论了EMT作为与癌细胞可塑性相关的关键程序之一，以及TGF-β对癌状态和功能的影响。我们进一步探索肿瘤微环境中癌症和其他细胞群的组成，并考虑与癌症治疗耐药性相关的程序的相关结果。

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.

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