Infections à papillomavirus

Abstract

Human papillomaviruses (HPVs) are responsible for frequent cutaneous and mucosal infections. The best known lesions are warts and genital condyloma. In the anogenital area, HPV are a true venereal disease. It is now well demonstrated that some HPVs are involved in the development of intraepithelial neoplasia and are considered as a necessary but not sufficient step for invasive cervical cancer. Organotypic cultures have allowed a better understanding of the viral cycle and carcinogenesis process. The in vitro production of virus-like particles has made possible a vaccinal approach.