Formulation, optimization, characterization and in-vitro drug release kinetics of atenolol loaded PLGA nanoparticles using 33 factorial design for oral delivery

Abstract

This work was aimed to formulate the atenolol loaded PLGA nanoparticles through optimizing formulation variables using 3³ factorial design. FTIR studies were performed to examine the interaction between the excipients used. These nanoparticles were characterized by size, shape, zeta potential, % drug entrapment efficiency, process yield and in-vitro drug release behavior. Different kinetics models were used to analyze the in-vitro drug release data. Preferred formulation showed particle size 192.6 ± 3.5 nm, PDI 0.234 ± 0.008, −32.4 mV zeta potential, drug entrapment efficiency 71.65 ± 1.8% and 78.32 ± 1.1% process yield. TEM results showed that these nanoparticles were spherical in shape and follow the Korsmeyer-Peppas model.