{"title":"Drug delivery behavior of titania nanotube arrays coated with chitosan polymer","authors":"Shahrzad Shidfar , Fariborz Tavangarian , Nahid Hassanzadeh Nemati , Abbas Fahami","doi":"10.1016/j.md.2017.09.002","DOIUrl":null,"url":null,"abstract":"<div><p><span>Titania nanotube (TNT) arrays with the length to diameter ratio of 85:1 were synthetized after anodizing the specimens at the anodizing voltage of 55</span> <!-->V for 2<!--> <!-->h. Ultrasonic cleaning procedure in deionized water caused the formation of micro-cracks, clusters of TNT bundles and distortion of the nanotubes; however, acetone medium decreased the risk of fracture and the formation of clusters. To control the drug delivery rate, chitosan polymer was deposited on the surface of TNTs using dip-coating process. The total release of TNTs with 0, 0.29 and 0.45<!--> <!-->μm chitosan coating thickness was about 6, 8 and 12<!--> <!-->days, respectively.</p></div>","PeriodicalId":100888,"journal":{"name":"Materials Discovery","volume":"8 ","pages":"Pages 9-17"},"PeriodicalIF":0.0000,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.md.2017.09.002","citationCount":"12","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Discovery","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2352924517300285","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 12
Abstract
Titania nanotube (TNT) arrays with the length to diameter ratio of 85:1 were synthetized after anodizing the specimens at the anodizing voltage of 55 V for 2 h. Ultrasonic cleaning procedure in deionized water caused the formation of micro-cracks, clusters of TNT bundles and distortion of the nanotubes; however, acetone medium decreased the risk of fracture and the formation of clusters. To control the drug delivery rate, chitosan polymer was deposited on the surface of TNTs using dip-coating process. The total release of TNTs with 0, 0.29 and 0.45 μm chitosan coating thickness was about 6, 8 and 12 days, respectively.
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