Tomás Pérez-Ruiz , Carmen Martı́nez-Lozano , Antonio Sanz , M.Teresa San Miguel
{"title":"Flow-injection chemiluminescent determination of phenothiazines in pharmaceutical preparations","authors":"Tomás Pérez-Ruiz , Carmen Martı́nez-Lozano , Antonio Sanz , M.Teresa San Miguel","doi":"10.1016/S1381-141X(99)00017-9","DOIUrl":null,"url":null,"abstract":"<div><p><span><span>A flow-injection configuration for the chemiluminescent (CL) determination of chlorpromazine, trimeprazine and </span>trifluoperazine<span> is proposed. The procedure is based on the oxidation of the drugs by Fe(III) perchlorate. The Fe(II) formed is measured by its catalytic effect on the CL luminol reaction in the absence of added oxidant. Linear calibration graphs were obtained between 2.0×10</span></span><sup>−6</sup> and 1.0×10<sup>−4</sup><span> M for all three drugs. The applicability of the method to the determination of these phenothiazines was demonstrated by investigating the effect of potential interferences and by analysing commercial pharmaceutical preparations.</span></p></div>","PeriodicalId":100862,"journal":{"name":"Laboratory Automation & Information Management","volume":"34 2","pages":"Pages 149-158"},"PeriodicalIF":0.0000,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S1381-141X(99)00017-9","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Laboratory Automation & Information Management","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1381141X99000179","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
A flow-injection configuration for the chemiluminescent (CL) determination of chlorpromazine, trimeprazine and trifluoperazine is proposed. The procedure is based on the oxidation of the drugs by Fe(III) perchlorate. The Fe(II) formed is measured by its catalytic effect on the CL luminol reaction in the absence of added oxidant. Linear calibration graphs were obtained between 2.0×10−6 and 1.0×10−4 M for all three drugs. The applicability of the method to the determination of these phenothiazines was demonstrated by investigating the effect of potential interferences and by analysing commercial pharmaceutical preparations.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
