Fabrication of Poly (d, l- Alanine)/minerals substituted hydroxyapatite bio-composite for bone tissue applications

Abstract

Eco-friendly ceramic/polymer bio-composite can address the constraints of traditional ceramic hard tissue replacements, such as, fragility and trouble in formability. However, the common processes for the preparation of ceramic/polymer bio-composite frequently utilize synthetic, natural polymers which might be destructive to tissues. In addition, the polymer materials may cover the bio-ceramics and obstruct their contact to the scaffold exterior, thus reducing the probability that the seeded bone cells will create exposure to the ceramics materials. In this investigation, a fresh ceramic/polymer bio-composite was created by high exposure of the bio-ceramics to the composite surface for effective bone tissue design. Poly (d, l- Alanine)/minerals (Mn, Cu) substituted-hydroxyapatite (MnCuHA/PA) bio-composite were fabricated by the solvent casting method. The chemical structure, crystalline nature, and morphology of as-prepared bio-composite were characterized by FTIR, XRD and SEM, EDX. Moreover, the in vitro antibacterial, in vitro cytocompatible properties of as-prepared bio-composite were evaluated. The physic-chemical and biological results showed MnCuHA/PA bio-composites are promising materials for bone tissue engineering applications.