Subcellular localization and transcriptional regulation of brain ryanodine receptors. Functional implications

IF 4.3 2区 生物学 Q2 CELL BIOLOGY Cell calcium Pub Date : 2023-11-04 DOI:10.1016/j.ceca.2023.102821
Rodrigo Torres , Cecilia Hidalgo
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Abstract

Ryanodine receptors (RyR) are intracellular Ca2+ channels localized in the endoplasmic reticulum, where they act as critical mediators of Ca2+-induced Ca2+ calcium release (CICR). In the brain, mammals express in both neurons, and non-neuronal cells, a combination of the three RyR-isoforms (RyR1–3). Pharmacological approaches, which do not distinguish between isoforms, have indicated that RyR-isoforms contribute to brain function. However, isoform-specific manipulations have revealed that RyR-isoforms display different subcellular localizations and are differentially associated with neuronal function. These findings raise the need to understand RyR-isoform specific transcriptional regulation, as this knowledge will help to elucidate the causes of neuronal dysfunction for a growing list of brain disorders that show altered RyR channel expression and function.

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脑ryanodine受体的亚细胞定位和转录调控。功能含义。
Ryanodine受体(RyR)是定位于内质网的细胞内Ca2+通道,在内质网中它们充当Ca2+诱导的Ca2+钙释放(CICR)的关键介质。在大脑中,哺乳动物在神经元和非神经元细胞中表达三种RyR亚型(RyR1-3)的组合。药理学方法不区分同种型,表明RyR同种型有助于大脑功能。然而,同种型特异性操作显示,RyR同种型表现出不同的亚细胞定位,并与神经元功能有不同的相关性。这些发现提出了理解RyR亚型特异性转录调控的必要性,因为这些知识将有助于阐明越来越多的大脑疾病的神经元功能障碍的原因,这些疾病显示出RyR通道表达和功能的改变。
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来源期刊
Cell calcium
Cell calcium 生物-细胞生物学
CiteScore
8.70
自引率
5.00%
发文量
115
审稿时长
35 days
期刊介绍: Cell Calcium covers the field of calcium metabolism and signalling in living systems, from aspects including inorganic chemistry, physiology, molecular biology and pathology. Topic themes include: Roles of calcium in regulating cellular events such as apoptosis, necrosis and organelle remodelling Influence of calcium regulation in affecting health and disease outcomes
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