Factores asociados con la respuesta a la terapia de privación androgénica en pacientes con cáncer de próstata y metástasis óseas en una institución

Abstract

Background

Metastatic prostate cancer is a frequent disease in Mexico. There are factors that can be associated with an adequate response to androgen deprivation therapy. Other therapeutic regimens have been proposed to improve results.

Aim

To identify factors influencing the response to androgen deprivation therapy in patients with prostate cancer and bone metastases.

Materials and methods

The study covered a 7-year period and included patients that presented with metastatic prostate cancer. Patient factors were evaluated during androgen deprivation therapy and follow-up. The association between factors and response was assessed through bivariate and multivariate analyses.

Results

Eighty-nine patients were included in the study. The factors associated with the development of castration resistance were: age, Gleason score, prostate-specific antigen reduction > 95%, less than 9 months to reach the nadir, and androgen deprivation therapy duration. Having received palliative radiotherapy and periods of intermittence were the factors that were contrastingly associated with cancer-specific mortality. Other factors related to prostate-specific antigen kinetics were not statistically significant in the multivariate analysis.

Conclusions

The described factors were associated with the response to androgen deprivation therapy in patients with metastatic prostate cancer.