Studies on the “Xiehuo” Effect and Compositions of Guangdong Herbal Tea

He Rongrong , Yao Xinsheng , Kurihara Hiroshi
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引用次数: 8

Abstract

In recent years, people are concerned about the “xiehuo” effect of Guangdong Herbal Tea (GHT). Study results found that GHT not only elevated the decreased levels of neurotransmitters and reduced immunocompetence in restraint stressed mice, but also prevented stressed mice against liver injury and inflammation. We also noticed that GHT accelerated the utilization of sugar energy and improved the capability of lipid tolerance in stressed mice. These results indicated that the effect of GHT on “xiehuo” may be related to its anti-stress effects. The results of mechanism study showed that GHT had the effects of anti-stress by regulating RNS and ROS generation in cells of restrained mice, at the same time regulating the activities and gene expressions of the key enzymes in the free radical chain reaction. Therefore, the anti-stress mechanism of GHT was related, at least partly, to the protection effect against oxidative stress in stress-loaded organisms. The main compounds of GHT identified were Gallic acid, Protocatechuic acid, (+)-Catechin, 4-Hydroxybenzoic acid, Caffeic acid, Ellagic acid-4-O-xylopyranoside, Isoquercitrin, and Ellagic acid. Results showed that most of these compounds are the active ingredients that are responsible for the “xiehuo” effect of GHT.

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广东凉茶的“泻火”作用及成分研究
摘要近年来,人们对广东凉茶的“泻火”作用十分关注。研究结果发现,GHT不仅提高了约束应激小鼠神经递质水平的降低和免疫活性的降低,而且可以预防应激小鼠的肝损伤和炎症。我们还注意到,GHT加速了应激小鼠糖能的利用,提高了脂质耐受能力。这些结果表明,GHT对“泻火”的作用可能与其抗应激作用有关。机制研究结果表明,GHT具有抗应激作用,其作用机制是通过调节抑制小鼠细胞中RNS和ROS的产生,同时调节自由基链式反应中关键酶的活性和基因表达。因此,GHT的抗应激机制至少部分与应激生物对氧化应激的保护作用有关。鉴定的GHT主要化合物有没食子酸、原儿茶酸、(+)-儿茶素、4-羟基苯甲酸、咖啡酸、芥子酸-4-O-吡喃木糖苷、异槲皮苷和芥子酸。结果表明,这些化合物中的大多数是GHT“泻火”作用的活性成分。
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