Oxidative stress and DNA damage–DNA repair system in vascular smooth muscle cells in artery and vein grafts

S.H. McLaren , D. Gao , L. Chen , R. Lin , J.R. Eshleman , V. Dawson , M.A. Trush , V.A. Bohr , M. Dizdaroglu , G.M. Williams , C. Wei
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引用次数: 8

Abstract

Graft failure in coronary artery bypass grafts (CABGs) utilizing the saphenous vein is significantly higher than in those utilizing the internal mammary artery (IMA) or the radial artery (RA). While a number of studies have described this phenomenon clinically, few have attempted to extensively examine the biological differences between vein and artery, or the short- and long-term effectiveness of their use. In addition, there is limited information on the role of reactive oxygen species (ROS) in the generation of oxidative stress in the vascular smooth muscle cell, which we speculate has a significant role in inducing apoptosis and, consequently, graft failure. The purpose of this review, thus, is to concisely describe the relationship among DNA damage, DNA repair and graft failure by examining (1) DNA lesions resulting from oxidative damage, such as 8-oxo-7,8-dihydroguanine, as well as their affiliation with human diseases, (2) biological differences in DNA damage and repair capabilities of both artery and vein, and (3) DNA repair mechanisms and the significance of several repair enzymes.

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动脉和静脉移植物中血管平滑肌细胞的氧化应激和DNA损伤-DNA修复系统
利用隐静脉的冠状动脉旁路移植术(CABG)的移植物失败率显著高于利用乳内动脉(IMA)或桡动脉(RA)的移植植物。虽然许多研究在临床上描述了这种现象,但很少有研究试图广泛检查静脉和动脉之间的生物学差异,或其使用的短期和长期有效性。此外,关于活性氧(ROS)在血管平滑肌细胞中产生氧化应激中的作用的信息有限,我们推测其在诱导细胞凋亡和移植失败中具有重要作用。因此,本综述的目的是通过检查(1)氧化损伤引起的DNA损伤,如8-氧-7,8-二氢鸟嘌呤,以及它们与人类疾病的关系,(2)动脉和静脉的DNA损伤和修复能力的生物学差异,(3)DNA修复机制及几种修复酶的意义。
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