What matters in aging is signaling for responsiveness

IF 12 1区医学 Q1 PHARMACOLOGY & PHARMACY Pharmacology & Therapeutics Pub Date : 2023-11-10 DOI:10.1016/j.pharmthera.2023.108560

Sang Chul Park , Young-Sam Lee , Kyung A Cho , Sung Young Kim , Yun-Il Lee , Seung-Rock Lee , In Kyoung Lim

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Abstract

Biological responsiveness refers to the capacity of living organisms to adapt to changes in both their internal and external environments through physiological and behavioral mechanisms. One of the prominent aspects of aging is the decline in this responsiveness, which can lead to a deterioration in the processes required for maintenance, survival, and growth. The vital link between physiological responsiveness and the essential life processes lies within the signaling systems. To devise effective strategies for controlling the aging process, a comprehensive reevaluation of this connecting loop is imperative.

This review aims to explore the impact of aging on signaling systems responsible for responsiveness and introduce a novel perspective on intervening in the aging process by restoring the compromised responsiveness. These innovative mechanistic approaches for modulating altered responsiveness hold the potential to illuminate the development of action plans aimed at controlling the aging process and treating age-related disorders.

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衰老过程中重要的是发出响应信号

生物反应是指生物体通过生理和行为机制适应内外环境变化的能力。衰老的一个突出方面是这种反应能力的下降，这可能导致维持、生存和生长所需过程的恶化。生理反应和基本生命过程之间的重要联系存在于信号系统中。为了制定有效的控制老化过程的策略，对这一连接回路进行全面的重新评估是必要的。本文旨在探讨衰老对负责反应性的信号系统的影响，并介绍通过恢复受损的反应性来干预衰老过程的新视角。这些调节反应性改变的创新机制方法有可能阐明旨在控制衰老过程和治疗年龄相关疾病的行动计划的发展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmacology & Therapeutics 医学-药学

CiteScore

23.00

自引率

0.70%

发文量

222

审稿时长

90 days

期刊介绍： Pharmacology & Therapeutics, in its 20th year, delivers lucid, critical, and authoritative reviews on current pharmacological topics.Articles, commissioned by the editor, follow specific author instructions.This journal maintains its scientific excellence and ranks among the top 10 most cited journals in pharmacology.