Measurements, mechanisms and potential therapy for preventing chemotherapy-induced cognitive impairment

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY Accounts of Chemical Research Pub Date : 2021-08-30 DOI:10.33425/2692-7918.1018

Jie Yin, Yuan-Yuan Han, Dong-Dong Shi

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Abstract

Cognitive impairment following chemotherapy, also called chemobrain, is reducing the life quality of millions of cancer patients. It is urgent to discover therapeutic methods against chemobrain. In fact, neither measurements nor mechanisms are yet to be defined. To discover efficient treatment on chemobrain, in this review, we firstly focus on applications of objective and accurate methods to study the measurement of chemobrain, such as Functional magnetic resonance imaging (fMRI) and positron emission tomography (PET). Furthermore, we highlight the potential mechanism of chemobrain including neuroinflammation, cell apoptosis and synaptic degeneration. Chemotherapy can induce neuroinflammation and cell apoptosis in brain. Synaptic plasticity also decreased in chemo-agent treated mice. Based on other cognitive impairment diseased, we also engaged in looking for effective treatment on cognitive impairment after chemotherapy in cancer patients. Synaptic repair, stem cell transplantation, Chinese medicine and psychological rehabilitation are all powerful candidates for treating chemobrain.

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预防化疗引起的认知障碍的测量、机制和潜在治疗

化疗后的认知障碍，也被称为化学脑，正在降低数百万癌症患者的生活质量。寻找治疗化学脑的方法迫在眉睫。事实上，测量和机制都还没有被定义。为了找到有效的治疗化学脑的方法，本文首先介绍了功能磁共振成像(fMRI)和正电子发射断层扫描(PET)等客观准确的方法在化学脑测量中的应用。此外，我们还强调了化学脑的潜在机制包括神经炎症、细胞凋亡和突触变性。化疗可引起脑内神经炎症和细胞凋亡。化疗小鼠的突触可塑性也有所下降。在其他认知功能障碍病变的基础上，我们也致力于寻找癌症患者化疗后认知功能障碍的有效治疗方法。突触修复、干细胞移植、中药和心理康复都是治疗化学脑的有力选择。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.

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