{"title":"A method to detect common features necessary for biological activity: Application of ANALOGS for aldose reductase inhibitors","authors":"Tamio Yasukawa ∗ , Katsunori Satoh , Noriaki Gotoh , Toshimasa Ishida ∗ , Shiegeuki Sumiya , Kunihiro Kitamura ∗","doi":"10.1016/0898-5529(90)90116-P","DOIUrl":null,"url":null,"abstract":"<div><p>A computer system for rational molecular design is described. The system, named as ANALOGS, provides the triangular elements consisting of functional atoms for the comparison of a number of stereochemically different compounds. Application of the system for aldose reductase inhibitors is described. The results obtained give some interesting information on the inhibitor-binding site of aldose reductase and on the structural features of the inhibitors.</p></div>","PeriodicalId":101214,"journal":{"name":"Tetrahedron Computer Methodology","volume":"3 1","pages":"Pages 3-10, IN1-IN2, 11-14"},"PeriodicalIF":0.0000,"publicationDate":"1990-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/0898-5529(90)90116-P","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Tetrahedron Computer Methodology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/089855299090116P","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
A computer system for rational molecular design is described. The system, named as ANALOGS, provides the triangular elements consisting of functional atoms for the comparison of a number of stereochemically different compounds. Application of the system for aldose reductase inhibitors is described. The results obtained give some interesting information on the inhibitor-binding site of aldose reductase and on the structural features of the inhibitors.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
