E. Mark, M. Klinge, D. Grønlund, J. Poulsen, V. Schlageter, S. Scott, K. Krogh, A. Drewes
{"title":"Ambulatory assessment of colonic motility using the electromagnetic capsule tracking system: Effect of opioids","authors":"E. Mark, M. Klinge, D. Grønlund, J. Poulsen, V. Schlageter, S. Scott, K. Krogh, A. Drewes","doi":"10.1111/nmo.13753","DOIUrl":null,"url":null,"abstract":"Opioid treatment often causes debilitating constipation. However, it is not well described how opioids affect colonic motility and whether opioid‐induced constipation is due to either a decrease of powerful peristaltic contractions or “uncoordinated” peristalsis. The present study aims to investigate the effect of oxycodone on parameters of colonic motility and to determine whether motility is normalized by the opioid antagonist naloxegol.","PeriodicalId":19104,"journal":{"name":"Neurogastroenterology & Motility","volume":"4 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2019-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurogastroenterology & Motility","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1111/nmo.13753","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
Opioid treatment often causes debilitating constipation. However, it is not well described how opioids affect colonic motility and whether opioid‐induced constipation is due to either a decrease of powerful peristaltic contractions or “uncoordinated” peristalsis. The present study aims to investigate the effect of oxycodone on parameters of colonic motility and to determine whether motility is normalized by the opioid antagonist naloxegol.
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